Kinetics of Circulating Damage-Associated Molecular Patterns in Sepsis

Figure 2

Changes of biomarkers. The time-courses of various biomarkers are plotted in the figure ((a) IL-6, (b) CRP, (c) PCT, (d) histone H3, (e) nucleosome, and (f) HMGB1). The levels of histone H3, nucleosome, and HMGB1 in healthy donors () were also shown in (d), (e), and (f). The levels of IL-6, CRP, and PCT peaked on Day 1 or Day 3 and decreased thereafter. In contrast, the level of histone H3 increased along with the days and reached its maximum level on Day 7. Data are expressed as means ± standard error. AU: absorbance units, IL-6: interleukin 6, CRP: c-reacting protein, PCT: procalcitonin, and HMGB1: high-mobility group protein Box 1.

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