Journal of Immunology Research / 2015 / Article / Tab 1

Research Article

Impaired Fas-Fas Ligand Interactions Result in Greater Recurrent Herpetic Stromal Keratitis in Mice

Table 1

HSV-1 shedding following UV-B reactivation.

Normal BALB/cBALB-gld BALB-lpr

EYES
 % of positive swabs@11%17%23%
 Total shedding days#72241
 Days of shedding/mouse1.2 ± 0.3 2.8 ± 0.252.9 + 0.6
 Reactivation rate33% (6/18 total)57% (8/14 total)54% (14/26 total)
 Final day of sheddingDay 5 Day 10Day 10
Trigeminal ganglia
 Genome copies × 102 ()6.5 ± 0.3 (10)10.4 ± 0.4 (5)11.1 + 0.3 (5)
 Titer day 3 after react. ()††845 ± 217 (4)1186 ± 159 (4)1075 + 245 (4)

The percent of positive swabs is the percentage of virus-positive eye swabs (140 to 286 eye swabs per group) over the 10-day period following UV-B irradiation. ( for both gld and lpr mice.)
#Total shedding days: number of days of positive swab. ( for both gld and lpr mice.)
Days of shedding/mouse are the number of days that a positive mouse shed virus. ( for both gld and lpr mice.)
Percentage of reactivation rate is the percentage of mice that were reactivated. ( for both gld and lpr mice.)
Final day of shedding was the last day that a mouse was positive for a particular group.
Mean number of genome copies from real-time PCR analysis. Statistical analysis did not indicate significant differences ().
††Titer of virus at day 3 after reactivation.