Impaired Fas-Fas Ligand Interactions Result in Greater Recurrent Herpetic Stromal Keratitis in Mice

Table 1

HSV-1 shedding following UV-B reactivation.

	Normal BALB/c	BALB-gld	BALB-lpr
EYES
% of positive swabs^@	11%	17%	23%
Total shedding days^#	7	22	41
Days of shedding/mouse^†	1.2 ± 0.3	2.8 ± 0.25	2.9 + 0.6
Reactivation rate^‡	33% (6/18 total)	57% (8/14 total)	54% (14/26 total)
Final day of shedding^∥	Day 5	Day 10	Day 10
Trigeminal ganglia
Genome copies × 10^2 ()	6.5 ± 0.3 (10)	10.4 ± 0.4 (5)	11.1 + 0.3 (5)
Titer day 3 after react. ()^††	845 ± 217 (4)	1186 ± 159 (4)	1075 + 245 (4)

The percent of positive swabs is the percentage of virus-positive eye swabs (140 to 286 eye swabs per group) over the 10-day period following UV-B irradiation. ( for both gld and lpr mice.)
^#Total shedding days: number of days of positive swab. ( for both gld and lpr mice.)
^†Days of shedding/mouse are the number of days that a positive mouse shed virus. ( for both gld and lpr mice.)
^‡Percentage of reactivation rate is the percentage of mice that were reactivated. ( for both gld and lpr mice.)
^∥Final day of shedding was the last day that a mouse was positive for a particular group.
Mean number of genome copies from real-time PCR analysis. Statistical analysis did not indicate significant differences ().
^††Titer of virus at day 3 after reactivation.