MGL Receptor and Immunity: When the Ligand Can Make the Difference

Figure 1

Schematic representation of type I and type II C-type lectins and lectin-like receptors. Type I CLRs (MR, DEC-205) are composed of a N-terminal cysteine-rich domain, a single fibronectin type II (FNII) domain, and 8–10 CTLDs all expressing CRDs. Type II CLRs (Langerin, DC-SIGN, MGL) or lectin-like receptors (Dectin-1) are composed of a single CTLD, an extracellular stalk region, a transmembrane region, and a N-terminal cytoplasmic tail with or without a signaling motif or proline-rich region. Langerin, DC-SIGN, MGL, and Dectin-1 express a CRD on their CTLD. CTLD, C-type lectin like domain; CLR, C-type lectin receptor; CRD, carbohydrate recognition domain; MR, mannose receptor; DC-SIGN, DC-specific ICAM3-grabbing nonintegrin; MGL, macrophage galactose type C-type lectin.