MGL Receptor and Immunity: When the Ligand Can Make the Difference

Figure 3

The structure of tumor antigen formulations internalized by MGL influences their processing and DC performance. (a) Recombinant Tn- protein remains blocked in DCs HLA class II compartment after internalization through MGL, while the shorter Tn- peptide (60 amino acids) is processed in HLA classes I and II compartments. (b) Effects induced on DC functions by MGL engagement with MoAb anti-MGL and Tn-MUC1 peptide.

(a)

(b)