Autoimmune Conditions in 235 Hemochromatosis Probands with HFE C282Y Homozygosity and Their First-Degree Relatives

Table 1

Comparisons of hemochromatosis probands with and without autoimmune conditions¹.

Characteristic	Autoimmune condition ()	No autoimmune condition ()	Value of ^2
Mean age, y	53 ± 13	48 ± 13	0.0747
Men, %	28.6 (10)	64.0 (128)	<0.0001
Family history, % ()^3	22.9 (8)	5.0 (10)	0.0002
Diabetes mellitus, % ()	14.3 (5)	14.0 (28)	0.9642
Heavy ethanol, % ()	5.7 (2)	14.0 (28)	0.1754
Elevated ALT, % ()^4	20.0 (7)	25.0 (50)	0.5243
Elevated AST, % ()^4	25.7 (9)	28.0 (56)	0.7803
NAFLD, % ()	17.1 (6)	19.0 (38)	0.7950
Viral hepatitis, % ()	2.9 (1)	5.0 (10)	0.4922
Cirrhosis, % ()	14.3 (5)	10.0 (20)	0.4481
Mean SF, µg/L	551 72, 4202	807 133, 4879]	0.0441
Mean FeQ, g^5	1.7 1.1, 2.5	2.0 1.7, 2.4	0.3962
HLA-A03 positivity, % ()	77.1 (27)	71.5 (143)	0.4911
HLA-A01, B08 positivity, % ()	14.3 (5)	11.0 (22)	0.5739
HLA-A02, B44 positivity, % ()	11.4 (4)	9.0 (18)	0.4911
HLA-A03, B07 positivity, % ()	48.6 (17)	41.0 (82)	0.4026
HLA-A03, B14 positivity, % ()	22.9 (8)	15.5 (31)	0.2805
HLA-A29, B44 positivity, % ()	0	5.5 (11)	0.1626

 ¹ALT, alanine aminotransferase; AST, aspartate aminotransferase; NAFLD, nonalcoholic fatty liver disease; SF, serum ferritin; FeQ, iron removed by phlebotomy to achieve iron depletion; HLA, human leukocyte antigen. Mean results are displayed as mean ± SD or mean [95% CI].
²These are nominal values of . Bonferroni correction for 18 comparisons yielded a revised for significance of <0.0028.
³History of autoimmune condition(s) in one or more first-degree family members.
⁴Elevated values were defined as >40 IU/L.
⁵These observations represent 215 probands because phlebotomy data were incomplete in 20 probands.