Autoimmune Conditions in 235 Hemochromatosis Probands with HFE C282Y Homozygosity and Their First-Degree Relatives

Table 2

Autoimmune conditions in 35 hemochromatosis probands¹.

Condition	Percentage ()
Hashimoto’s thyroiditis^2	54.3 (19)
Rheumatoid arthritis^3	11.4 (4)
Ankylosing spondylitis^4	5.7 (2)
Mixed connective tissue disorder	5.7 (2)
Myasthenia gravis	5.7 (2)
Pernicious anemia	5.7 (2)
Sarcoidosis	5.7 (2)
Ulcerative colitis	5.7 (2)
Autoimmune hemolytic anemia^5	2.9 (1)
Crohn’s disease	2.9 (1)
Elevated antinuclear antibody^6	2.9 (1)
Graves’ disease	2.9 (1)
Polymyalgia rheumatica	2.9 (1)
Primary biliary cirrhosis	2.9 (1)
Psoriasis	2.9 (1)
Raynaud’s phenomenon	2.9 (1)
Scleroderma	2.9 (1)
Sjögren’s syndrome	2.9 (1)
Systemic lupus erythematosus	2.9 (1)

 ¹Six probands had two or more autoimmune conditions. Two men had both Hashimoto’s thyroiditis and pernicious anemia. One woman had both Hashimoto’s thyroiditis and Crohn’s disease. One woman had Hashimoto’s thyroiditis, polymyalgia rheumatica, and systemic lupus erythematosus. One woman had Hashimoto’s thyroiditis, Raynaud’s phenomenon, sarcoidosis, scleroderma, and Sjögren’s syndrome. One woman had both ulcerative colitis and biliary cirrhosis.
²Of 235 probands, 14 women and 5 men had Hashimoto’s thyroiditis (8.1% 5.1, 12.5).
³Of 235 probands, 2 men and 2 women had rheumatoid arthritis (1.7% 0.6, 4.6).
⁴Of 235 probands, 2 men had ankylosing spondylitis (0.0085 0.0015, 0.0337).
⁵Mediated by IgG and complement.
⁶This proband had anti-nuclear antibody >1 : 320 without other manifestation of autoimmunity. Elevated anti-nuclear antibodies (>1 : 80) in other probands were interpreted as part of broader autoimmune condition diagnoses named separately.