Autoimmune Conditions in 235 Hemochromatosis Probands with HFE C282Y Homozygosity and Their First-Degree Relatives

Table 3

Autoimmune conditions in 18 first-degree relatives of 235 hemochromatosis probands¹.

Conditions in relatives	35 probands with autoimmune conditions	200 probands without autoimmune conditions	Value of ^2
Hashimoto’s thyroiditis	11.4 (4)	0.5 (1)	0.0019
Crohn’s disease	5.7 (2)	0	0.0216
Graves’ disease	2.9 (1)	0.5 (1)	0.2762
Rheumatoid arthritis	2.9 (1)	2.0 (4)	0.5569
Sarcoidosis	2.9 (1)	0	0.1489
Vitiligo	2.9 (1)	0	0.1489
Addison’s disease	0	0.5 (1)	0.8511
Multiple sclerosis	0	0.5 (1)	0.8511
Pernicious anemia	0	0.5 (1)	0.8511
Scleroderma	0	0.5 (1)	0.8511

 ¹Observations are displayed as % () of the proband subgroups who had first-degree relatives with the indicated conditions. Each of two relatives had two autoimmune conditions.
²These are nominal values of . Bonferroni correction for 10 comparisons yielded a revised for significance of <0.0050.