Autoimmune Conditions in 235 Hemochromatosis Probands with HFE C282Y Homozygosity and Their First-Degree Relatives

Table 4

Autoimmune conditions previously reported in persons with hemochromatosis¹.

Condition	Reference
Autoimmune hemolytic anemia	[14]
Celiac disease	[17, 19, 26–29]
Diabetes mellitus type 1^2	[30]
Hashimoto’s thyroiditis	[16, 31, 32]
Hyperthyroidism or Graves’ disease	[16, 33–35]
Immune thrombocytopenia	[34]
Myasthenia gravis^3	[36]
Pernicious anemia	[37, 38]
Psoriasis	[39]
Rheumatoid arthritis	[40, 41]
Sarcoidosis^4	[18, 42]
Schnitzler’s syndrome	[43]
Sclerosing cholangitis^5	[44]
Ulcerative colitis^5	[44]
Vitiligo	[15]

 ¹Hemochromatosis was defined as an adult-onset condition typical of HFE hemochromatosis in European white adults characterized by iron phenotyping, HLA typing or haplotyping, or HFE C282Y homozygosity. One HFE C282Y homozygote had collagenous sprue, a rare condition of uncertain etiology [45].
²Autoimmunity was not mentioned in descriptions of study subjects.
³This man had pure red cell aplasia of undefined cause.
⁴The case of a woman with sarcoidosis included herein was reported previously [18].
⁵Ulcerative colitis and sclerosing cholangitis occurred in the same man.