Research Article
NKG2D Signaling Leads to NK Cell Mediated Lysis of Childhood AML
| | Healthy donors | HLA type | HLA I ligand | Corresponding inhibitory KIR | KIR mismatch |
| | Donor A | C1/C2 | bw6+/bw4+ | cw3+/cw4+ | KIR2DL1, KIR2DL2/3, KIR3DL1 | — | | Donor B | C1/C1 | bw6+/bw4+ | cw3+/cw3+ | KIR2DL2/3, KIR3DL1 | KIR2DL1 |
| | Childhood AML blasts | | | | | | | AML-1 FAB M0 | C1/C1 | bw6+/bw4+ | cw3+/cw3+ | KIR2DL2/3, KIR3DL1 | KIR2DL1 | | AML-2 FAB M0 | C2/C2 | bw6+/bw4+ | cw4+/cw4+ | KIR2DL1, KIR3DL1 | KIR2DL2/3 | | AML-3 FAB M2 | C1/C1 | bw4+/bw4+ | cw3+/cw3+ | KIR2DL2/3, KIR3DL1 | KIR2DL1 | | AML-4 FAB M2 | C1/C2 | bw6+/bw6+ | cw3+/cw4+ | KIR2DL1, KIR2DL2/3 | KIR3DL1 | | AML-5 FAB M4 | C2/C2 | bw6+/bw4+ | cw4+/cw4+ | KIR2DL1, KIR3DL1 | KIR2DL2/3 | | AML-6 FAB M4 | C1/C2 | bw6+/bw4+ | cw3+/cw4+ | KIR2DL1, KIR2DL2/3, KIR3DL1 | — | | AML-7 FAB M5 | C2/C2 | bw6+/bw6+ | cw4+/cw4+ | KIR2DL1 | KIR2DL2/3, KIR3DL1 | | AML-8 FAB M5 | C1/C2 | bw4+/bw4+ | cw3+/cw4+ | KIR2DL1, KIR2DL2/3, KIR3DL1 | — | | AML-9 FAB M5 | C1/C1 | bw6+/bw4+ | cw3+/cw3+ | KIR2DL2/3, KIR3DL1 | KIR2DL1 | | AML-10 FAB M5 | C1/C1 | bw6+/bw6+ | cw3+/cw3+ | KIR2DL2/3 | KIR2DL1, KIR3DL1 | | AML-11 FAB M5b | C1/C2 | bw6+/bw4+ | cw3+/cw4+ | KIR2DL1, KIR2DL2/3, KIR3DL1 | — | | AML-12 FAB M6 | C1/C2 | bw6+/bw6+ | cw3+/cw4+ | KIR2DL1, KIR2DL2/3 | KIR3DL1 | | AML-13 FAB M6 | C1/C1 | bw6+/bw4+ | cw3+/cw3+ | KIR2DL2/3, KIR3DL1 | KIR2DL1 | | AML-14 FAB M6 | C2/C2 | bw6+/bw4+ | cw4+/cw4+ | KIR2DL1, KIR3DL1 | KIR2DL2/3 |
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