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Journal of Immunology Research
Volume 2015, Article ID 478412, 10 pages
http://dx.doi.org/10.1155/2015/478412
Research Article

MBL2 Genotypes and Their Associations with MBL Levels and NICU Morbidity in a Cohort of Greek Neonates

1Department of Immunology & Histocompatibility, School of Health Sciences, Faculty of Medicine, University Hospital of Larissa, University of Thessaly, Biopolis 3, 41500 Larissa, Greece
2Neonatal Intensive Care Unit, School of Health Sciences, Faculty of Medicine, University Hospital of Larissa, University of Thessaly, Biopolis 3, 41500 Larissa, Greece
3Neonatal Intensive Care Unit, General Hospital of Nikea “Agios Panteleimon”, 11634 Athens, Greece
4Intensive Care Unit, Thriassion General Hospital of Eleusis, 19600 Athens, Greece

Received 7 October 2014; Revised 23 February 2015; Accepted 28 February 2015

Academic Editor: Eyad Elkord

Copyright © 2015 Matthaios Speletas et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. T. Strunk and D. Burgner, “Genetic susceptibility to neonatal infection,” Current Opinion in Infectious Diseases, vol. 19, no. 3, pp. 259–263, 2006. View at Publisher · View at Google Scholar · View at Scopus
  2. O. Levy, “Innate immunity of the newborn: basic mechanisms and clinical correlates,” Nature Reviews Immunology, vol. 7, no. 5, pp. 379–390, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. C. L. Hedberg, K. Adcock, J. Martin, J. Loggins, T. E. Kruger, and R. J. Baier, “Tumor necrosis factor α—308 polymorphism associated with increased sepsis mortality in ventilated very low birth weight infants,” The Pediatric Infectious Disease Journal, vol. 23, no. 5, pp. 424–428, 2004. View at Publisher · View at Google Scholar · View at Scopus
  4. D. Harding, S. Dhamrait, A. Millar et al., “Is interleukin-6 -174 genotype associated with the development of septicemia in preterm infants?” Pediatrics, vol. 112, no. 4, pp. 800–803, 2003. View at Publisher · View at Google Scholar · View at Scopus
  5. F. N. J. Frakking, N. Brouwer, D. Zweers et al., “High prevalence of mannose-binding lectin (MBL) deficiency in premature neonates,” Clinical and Experimental Immunology, vol. 145, no. 1, pp. 5–12, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. O. A. Bodamer, G. Mitterer, W. Maurer, A. Pollak, M. W. Mueller, and W. M. Schmidt, “Evidence for an association between mannose-binding lectin 2 (MBL2) gene polymorphisms and pre-term birth,” Genetics in Medicine, vol. 8, no. 8, pp. 518–524, 2006. View at Publisher · View at Google Scholar · View at Scopus
  7. W. C. van der Zwet, A. Catsburg, R. M. van Elburg, P. H. M. Savelkoul, and C. M. J. E. Vandenbroucke-grauls, “Mannose-binding lectin (MBL) genotype in relation to risk of nosocomial infection in pre-term neonates in the neonatal intensive care unit,” Clinical Microbiology and Infection, vol. 14, no. 2, pp. 130–135, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. A. St. Swierzko, A. P. M. Atkinson, M. Cedzynski et al., “Two factors of the lectin pathway of complement, l-ficolin and mannan-binding lectin, and their associations with prematurity, low birthweight and infections in a large cohort of Polish neonates,” Molecular Immunology, vol. 46, no. 4, pp. 551–558, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. A. Hilgendorff, K. Heidinger, A. Pfeiffer et al., “Association of polymorphisms in the mannose-binding lectin gene and pulmonary morbidity in preterm infants,” Genes and Immunity, vol. 8, no. 8, pp. 671–677, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. F. de Benedetti, C. Auriti, L. E. D'Urbano et al., “Low serum levels of mannose binding lectin are a risk factor for neonatal sepsis,” Pediatric Research, vol. 61, no. 3, pp. 325–328, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. P. Ahrens, E. Kattner, B. Köhler et al., “Mutations of genes involved in the innate immune system as predictors of sepsis in very low birth weight infants,” Pediatric Research, vol. 55, no. 4, pp. 652–656, 2004. View at Publisher · View at Google Scholar · View at Scopus
  12. F. N. J. Frakking, N. Brouwer, N. K. A. van Eijkelenburg et al., “Low mannose-binding lectin (MBL) levels in neonates with pneumonia and sepsis,” Clinical and Experimental Immunology, vol. 150, no. 2, pp. 255–262, 2007. View at Publisher · View at Google Scholar · View at Scopus
  13. M. W. Turner, “The role of mannose-binding lectin in health and disease,” Molecular Immunology, vol. 40, no. 7, pp. 423–429, 2003. View at Publisher · View at Google Scholar · View at Scopus
  14. S. Thiel, T. Vorup-Jensen, C. M. Stover et al., “A second serine protease associated with mannan-binding lectin that activates complement,” Nature, vol. 386, no. 6624, pp. 506–510, 1997. View at Publisher · View at Google Scholar · View at Scopus
  15. A. J. Tenner, S. L. Robinson, and R. A. B. Ezekowitz, “Mannose binding protein (MBP) enhances mononuclear phagocyte function via a receptor that contains the 126,000 Mr component of the C1q receptor,” Immunity, vol. 3, no. 4, pp. 485–493, 1995. View at Publisher · View at Google Scholar · View at Scopus
  16. I. Ghiran, S. F. Barbashov, L. B. Klickstein, S. W. Tas, J. C. Jensenius, and A. Nicholson-Weller, “Complement receptor 1/CD35 is a receptor for mannan-binding lectin,” The Journal of Experimental Medicine, vol. 192, no. 12, pp. 1797–1808, 2000. View at Publisher · View at Google Scholar · View at Scopus
  17. S. Sallenbach, S. Thiel, C. Aebi et al., “Serum concentrations of lectin-pathway components in healthy neonates, childrens and adults: mannan-binding lectin (MBL), M-, L-, and H-ficolin, and MBL-associated serine protease-2 (MASP-2),” Pediatric Allergy and Immunology, vol. 22, no. 4, pp. 424–430, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. P. Garred, F. Larsen, J. Seyfarth, R. Fujita, and H. O. Madsen, “Mannose-binding lectin and its genetic variants,” Genes and Immunity, vol. 7, no. 2, pp. 85–94, 2006. View at Publisher · View at Google Scholar · View at Scopus
  19. H. O. Madsen, P. Garred, S. Thiel et al., “Interplay between promoter and structural gene variants control basal serum level of mannan-binding protein,” Journal of Immunology, vol. 155, no. 6, pp. 3013–3020, 1995. View at Google Scholar · View at Scopus
  20. A. Koch, M. Melbye, P. Sørensen et al., “Acute respiratory tract infections and mannose-binding lectin insufficiency during early childhood,” The Journal of the American Medical Association, vol. 285, no. 10, pp. 1316–1321, 2001. View at Publisher · View at Google Scholar · View at Scopus
  21. J. A. Summerfield, M. Sumiya, M. Levin, and M. W. Turner, “Association of mutations in mannose binding protein gene with childhood infection in consecutive hospital series,” British Medical Journal, vol. 314, no. 7089, pp. 1229–1232, 1997. View at Publisher · View at Google Scholar · View at Scopus
  22. O. W. Neth, U. Bacher, P. Das et al., “Influence of mannose-binding lectin genotypes and serostatus in allo-SCT: analysis of 131 recipients and donors,” Bone Marrow Transplantation, vol. 45, no. 1, pp. 13–19, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. J. R. Fioretto and W. B. de Carvalho, “Temporal evolution of acute respiratory distress syndrome definitions,” Jornal de Pediatria, vol. 89, no. 6, pp. 523–530, 2013. View at Publisher · View at Google Scholar · View at Scopus
  24. S. K. Tin, L. Y. Lee, J. Thumboo, D. R. Koh, and K. Y. Fong, “PCR-RFLP genotyping for exon 1 and promoter region mutations of the human mannose binding lectin (MBL-2) gene,” Journal of Immunological Methods, vol. 303, no. 1-2, pp. 148–151, 2005. View at Publisher · View at Google Scholar · View at Scopus
  25. J. Aittoniemi, A. Miettinen, P. Laippala et al., “Age-dependent variation in the serum concentration of mannan-binding protein,” Acta Paediatrica, International Journal of Paediatrics, vol. 85, no. 8, pp. 906–909, 1996. View at Publisher · View at Google Scholar · View at Scopus
  26. Z. C. Chroneos, Z. Sever-Chroneos, and V. L. Shepherd, “Pulmonary surfactant: an immunological perspective,” Cellular Physiology and Biochemistry, vol. 25, no. 1, pp. 13–26, 2010. View at Publisher · View at Google Scholar · View at Scopus
  27. H. L. Halliday, “Surfactants: past, present and future,” Journal of Perinatology, vol. 28, supplement 1, pp. S47–S56, 2008. View at Publisher · View at Google Scholar · View at Scopus
  28. D. G. Sweet, V. Carnielli, G. Greisen et al., “European consensus guidelines on the management of neonatal respiratory distress syndrome in preterm infants—2010 update,” Neonatology, vol. 97, no. 4, pp. 402–417, 2010. View at Publisher · View at Google Scholar · View at Scopus
  29. M. N. Gong, W. Zhou, P. L. Williams, B. T. Thompson, L. Pothier, and D. C. Christiani, “Polymorphisms in the mannose binding lectin-2 gene and acute respiratory distress syndrome,” Critical Care Medicine, vol. 35, no. 1, pp. 48–56, 2007. View at Publisher · View at Google Scholar · View at Scopus
  30. C. L. Lin, L. K. Siu, J. C. Lin et al., “Mannose-binding lectin gene polymorphism contributes to recurrence of infective exacerbation in patients with COPD,” Chest, vol. 139, no. 1, pp. 43–51, 2011. View at Publisher · View at Google Scholar · View at Scopus
  31. J. D. Chalmers, G. B. Fleming, A. T. Hill, and D. C. Kilpatrick, “Impact of mannose-binding lectin insufficiency on the course of cystic fibrosis: a review and meta-analysis,” Glycobiology, vol. 21, no. 3, pp. 271–282, 2011. View at Publisher · View at Google Scholar · View at Scopus
  32. B. Fevang, T. E. Mollnes, A. M. Holm et al., “Common variable immunodeficiency and the complement system; low mannose-binding lectin levels are associated with bronchiectasis,” Clinical & Experimental Immunology, vol. 142, no. 3, pp. 576–584, 2005. View at Publisher · View at Google Scholar · View at Scopus
  33. J. Litzman, T. Freiberger, B. Grimbacher et al., “Mannose-binding lectin gene polymorphic variants predispose to the development of bronchopulmonary complications but have no influence on other clinical and laboratory symptoms or signs of common variable immunodeficiency,” Clinical and Experimental Immunology, vol. 153, no. 3, pp. 324–330, 2008. View at Publisher · View at Google Scholar · View at Scopus
  34. J. D. Chalmers, B. J. McHugh, C. Doherty et al., “Mannose-binding lectin deficiency and disease severity in non-cystic fibrosis bronchiectasis: a prospective study,” The Lancet Respiratory Medicine, vol. 1, no. 3, pp. 224–232, 2013. View at Publisher · View at Google Scholar · View at Scopus
  35. P. Garred, T. Pressler, H. O. Madsen et al., “Association of mannose-binding lectin gene heterogeneity with severity of lung disease and survival in cystic fibrosis,” The Journal of Clinical Investigation, vol. 104, no. 4, pp. 431–437, 1999. View at Publisher · View at Google Scholar · View at Scopus
  36. P. Garred, T. Pressler, S. Lanng et al., “Mannose-binding lectin (MBL) therapy in an MBL-deficient patient with severe cystic fibrosis lung disease,” Pediatric Pulmonology, vol. 33, no. 3, pp. 201–207, 2002. View at Publisher · View at Google Scholar · View at Scopus
  37. B. A. Seaton, E. C. Crouch, F. X. McCormack, J. F. Head, K. L. Hartshorn, and R. Mendelsohn, “Structural determinants of pattern recognition by lung collectins,” Innate Immunity, vol. 16, no. 3, pp. 143–150, 2010. View at Publisher · View at Google Scholar · View at Scopus
  38. P. Eggleton and K. B. Reid, “Lung surfactant proteins involved in innate immunity,” Current Opinion in Immunology, vol. 11, no. 1, pp. 28–33, 1999. View at Publisher · View at Google Scholar · View at Scopus
  39. K. Duus, N. M. Thielens, M. Lacroix et al., “CD91 interacts with mannan-binding lectin (MBL) through the MBL-associated serine protease-binding site,” FEBS Journal, vol. 277, no. 23, pp. 4956–4964, 2010. View at Publisher · View at Google Scholar · View at Scopus
  40. N. Palaniyar, J. Nadesalingam, H. Clark, M. J. Shih, A. W. Dodds, and K. B. M. Reid, “Nucleic acid is a novel ligand for innate, immune pattern recognition collectins surfactant proteins A and D and mannose-binding lectin,” The Journal of Biological Chemistry, vol. 279, no. 31, pp. 32728–32736, 2004. View at Publisher · View at Google Scholar · View at Scopus