MBL2 Genotypes and Their Associations with MBL Levels and NICU Morbidity in a Cohort of Greek Neonates
Table 2
Overview of MBL concentrations and MBL2 genotype.
Healthy
NICU (neοnatal intensive care unit)
(number 150)
Total (number 134)
Term (number 83)
Preterm (number 51)
MBL (ng/mL)
MBL (ng/mL)
MBL (ng/mL)
MBL (ng/mL)
(%)
Median (range)
(%)
Median (range)
, values*
(%)
Median (range)
(%)
Median (range)
, values#
MBL2 genotype
YA/YΑ
50 (33.3)
1725 (100–4110)
42 (31.3)
1515 (100–3000)
0.798 0.082
23 (27.7)
1610 (190–3000)
19 (37.3)
1190 (100–2200)
0.407 0.033
YA/ΧA
26 (17.3)
1290 (550–1990)
21 (15.7)
1230 (40–2080)
0.750 0.480
13 (15.7)
1350 (740–2080)
8 (15.7)
1055 (40–1690)
0.998 0.082
ΧA/ΧA
6 (4.0)
885 (700–1600)
9 (6.7)
600 (340–1790)
0.333 0.088
7 (8.4)
600 (420–1090)
2 (3.9)
1065 (340–1790)
0.341 NA
YA/O
42 (28.0)
235 (10–2440)
33 (26.7)
180 (40–1350)
0.623 0.452
24 (28.9)
210 (40–1350)
9 (17.6)
105 (50–710)
0.247 0.384
XA/O
16 (10.7)
45 (10–430)
17 (12.7)
30 (10–210)
0.637 0.065
11 (13.3)
10 (10–210)
6 (11.8)
10 (10–200)
0.825 0.339
O/O
10 (6.7)
10 (10–290)
12 (9.0)
10 (10–200)
0.505 0.473
5 (6.0)
10 (10–10)
7 (13.7)
10 (10–200)
0.169 1.000
MBL2 genotype groups
High YA/YA, YA/XA
76 (50.7)
1600 (100–4110)
63 (47.0)
1350 (40–3000)
0.719 0.068
36 (43.4)
1600 (190–3000)
27 (52.9)
1170 (40–2200)
0.521 0.012
Medium XA/XA, YA/O
48 (32.0)
260 (10–2440)
42 (31.3)
265 (10–1790)
0.932 0.833
31 (37.3)
330 (40–1350)
11 (21.6)
180 (50–1790)
0.160 0.367
Low XA/O, O/O
26 (17.3)
25 (10–430)
29 (21.6)
10 (10–210)
0.451 0.044
16 (19.3)
10 (10–210)
13 (25.5)
10 (10–200)
0.499 0.569
MBL functional deficiency
value∧
value∧
MBL levels ≤150 ng/mL
30 (10.0)
42 (31.3)
0.091
24 (28.9)
18 (35.3)
0.578
MBL levels ≤400 ng/mL
61 (40.7)
62 (46.3)
0.550
35 (42.2)
27 (52.9)
0.465
MBL levels ≤700 ng/mL
68 (45.3)
72 (53.7)
0.411
44 (53.0)
28 (54.9)
0.907
Statistical significance and refer to comparison of MBL2 genotypes and MBL concentrations between NICU patients with healthy controls (chi-square and Mann-Whitney test, resp.); # and refer to comparison of MBL2 genotypes and MBL concentrations between term and preterm neonates of NICU (chi-square and Mann-Whitney test, resp.); ∧ and refer to comparison of MBL functional deficiency (using 3 different cut-offs) between healthy and NICU neonates and between term and preterm neonates of NICU, respectively (chi-square test).
