Research Article

MBL2 Genotypes and Their Associations with MBL Levels and NICU Morbidity in a Cohort of Greek Neonates

Table 3

Overview of MBL2 genotypes and haplotypes in the subjects of the study.

NICU (neonatal intensive care)
Healthy
( 150)
Total
( 134)
Term
( 83)
Preterm
( 51)
(%) (%)* (%) (%)*

MBL2 genotypes
YA/YA
 HYA/HYA13 (8.7)10 (7.5)0.7326 (7.2)4 (7.8)0.903
 LYA/LYA7 (4.7)4 (3.0)0.4801 (1.2)3 (5.9)0.136
 HYA/LYA31 (20.7)28 (20.9)0.96916 (19.3)12 (23.5)0.636

YΑΑ
 LYA/LXA9 (6.0)10 (7.5)0.6454 (4.8)6 (11.8)0.171
 HYA/LXA16 (10.7)11 (8.2)0.5219 (10.8)2 (3.9)0.188

ΧΑΑ
 LXA/LXA6 (4.0)9 (6.7)0.3337 (8.4)2 (3.9)0.341

YΑ/O
 HYA/HYD4 (2.7)2 (1.5)0.5012 (2.4)0 (0)0.270
 HYA/LYB26 (17.3)20 (14.9)0.64015 (18.1)5 (9.8)0.257
 HYA/LYC0 (0)1 (0.7)0.2911 (1.2)0 (0)0.434
 LYA/HYD4 (2.7)6 (4.5)0.4253 (3.6)3 (5.9)0.557
 LYA/LYB8 (5.3)4 (3.0)0.3463 (3.6)1 (2.0)0.595

XA/O
 LXA/LYB9 (6.0)14 (10.4)0.2069 (10.8)5 (9.8)0.863
 LXA/HYD7 (4.7)2 (1.5)0.1391 (1.2)1 (2.0)0.730
 LXA/LYC0 (0)1 (0.7)0.2911 (1.2)0 (0)0.434

O/O
 LYB/LYB5 (3.3)7 (5.2)0.4494 (4.8)3 (5.9)0.799
 LYB/HYD5 (3.3)3 (2.2)0.5881 (1.2)2 (3.9)0.314
 HYD/HYD0 (0)2 (1.5)0.1360 (0)2 (3.9)0.075

MBL2 haplotypes
HYA103 (34.3)82 (30.6)0.49855 (33.1)27 (26.5)0.399
LYA66 (22.0)56 (20.9)0.79728 (18.9)28 (27.5)0.097
LXA53 (17.7)56 (20.9)0.42238 (22.9)18 (17.6)0.404
LYB58 (19.3)55 (20.5)0.77236 (21.7)19 (18.6)0.624
HYD20 (6.7)17 (6.3)0.8847 (4.2)10 (9.8)0.089
LYC02 (0.7)0.1352 (1.2)0 (0)0.269

Statistical significance (chi-square test) refers to comparison of MBL2 genotypes between NICU and healthy neonates and to comparison of MBL2 genotypes between term and preterm neonates of NICU.