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Journal of Immunology Research
Volume 2015 (2015), Article ID 478753, 12 pages
http://dx.doi.org/10.1155/2015/478753
Research Article

TACI Expression and Signaling in Chronic Lymphocytic Leukemia

1Department of Immunology & Histocompatibility, Faculty of Medicine, School of Health Sciences, University of Thessaly, Biopolis 3, 41500 Larissa, Greece
2Department of Hematology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Biopolis 3, 41500 Larissa, Greece
3Fourth Department of Internal Medicine, Ippokration Hospital, Aristotle University of Thessaloniki, Konstantinoupoleos 49, 54642 Thessaloniki, Greece
4Department of Hematology, Papageorgiou General Hospital, Periferiaki Odos Thessalonikis, Nea Efkarpia, 56429 Thessaloniki, Greece

Received 20 November 2014; Accepted 15 March 2015

Academic Editor: Jacek Tabarkiewicz

Copyright © 2015 Antigoni Mamara et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary Figure 1. Cumulative survival of CLL patients of the study according to the presence of (A) autoimmune manifestations (clinical and/or laboratory), and (B) monoclonal M-component.

Supplementary Figure 2. Frequency of specific IGHV genes identified in the patients of the study, according to their mutational status (A) (somatic hypermutation greater or equal to 3% different from the germline V gene sequence is considered as mutated, whereas less than 3% difference is considered as unmutated; details about the cut-off used are presented in the text). Cumulative survival of CLL patients of the study according to their mutational status (B).

Supplementary Figure 3. Comparison of mRNA and protein TNFRSF13B/TACI expression (mean values) in 19 CLL patients of the study.

Supplementary Table 1. Immunophenotyping of 19 healthy individuals analyzed in this study.

  1. Supplementary Materials