Journal of Immunology Research / 2015 / Article / Fig 2

Review Article

The Danger Model Approach to the Pathogenesis of the Rheumatic Diseases

Figure 2

The sun-burned defective DNA repairer keratinocyte in SLE. The exposure of the keratinocyte DNA to UV radiation infringes DNA damage, which cannot be normally repaired because of faulty enzymes. DNA repairing proteins are upregulated and therefore presented as antigens; in the stressed context costimulatory molecules are upregulated and an autoimmune response toward nucleoproteins is settled. Repetitive cycles of UV radiation perpetuate the immune process because the tissue is harmed again and releases danger mediators.

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