SP140L, an Evolutionarily Recent Member of the SP100 Family, Is an Autoantigen in Primary Biliary Cirrhosis

Figure 1

Sequence analysis of the SP100 gene family. (a) Genomic region of human chromosome 2 comprising the SP100 gene family. (b) Genomic structure of the SP140L gene. Exons are marked with solid boxes and numbered. Exon 2 (red) is not found in our cDNAs. Exon 11 and a fragment of exon 16 (purple) were spliced in some of our transcripts. (c) Structure of the SP140L protein and its isoforms and comparison to other SP100 family proteins. HSR/CARD (homogenously stained region/caspase recruitment domain), SAND (SP100, AIRE, NucP41/P75, and DEAF), PHD (plant homeodomain type zinc finger), Bromo (bromodomain), and PxVxL (HP1 binding motif). (d) Schematic representation of the putative genomic rearrangements creating the SP140L gene.