Applying the Concept of Peptide Uniqueness to Anti-Polio Vaccination
Table 3
Conservativeness of epitopic PV peptide regions among 43 PV strains and variants.
PV strain
UniProt/Swiss-Prot entry
aa Pos 464
aa Pos 708
aa Pos 748
aa Pos 763
aa Pos 783
aa Pos 835
aa Pos 847
PV1 Mahoney
P03300
FMMATG
RFDME
KWDDYTWQT
FYTYG
AYSHFYD
KIRVY
VWCPR
PV1 Sabin
P03301
SMMATG
RFDME
KWDDYTWQT
FYTYG
AYSHFYD
KIRVY
VWCPR
PV3 P3/Leon/37
P03302
SMMATG
RFDME
sWDDYTWQT
FYTYG
AYSHFYD
KvRiY
VWCPR
PV3 23127
P06209
SMMATG
RFDME
sWDDYTWQT
FYTYG
AYSHFYD
KvRvY
VWCPR
PV1 isolated
Q9Q281
SMMATG
RFDME
KWDDYTWQT
FYTYG
AYSHFYD
KvRVY
VWCPR
PV1 isolated
Q9Q280
SMMATG
RFDME
KWDDYTWQT
FYTYG
AYSHFYD
KIRVY
VWCPR
PV1 isolated
Q71AZ9
SMMATG
RFDME
KWDDYTWQT
FYTYG
AYSHFYD
KIRVY
VWCPR
PV1 isolated
Q5TLH5
SMMATG
RFDME
KWDDYTWQT
FYTYG
AYSHFYD
KIRVY
VWCPR
PV1-HAI01008C2
D1YSI9
SMMATG
RFDME
KWDDYTWQT
FYTYG
AYSHFYD
KIRVY
VWCPR
PV1-HAI01009
D1YSJ1
SMMATG
RFDME
KWDDYTWQT
FYTYG
AYSHFYD
KIRVY
VWCPR
PV1-HAI01008
D1YSJ2
SMMATG
RFDME
KWDDYTWQT
FYTYG
AYSHFYD
KIRVY
VWCPR
PV1-HAI01002
D1YSJ3
SMMATG
RFDME
KWDDYTWQT
FYTYG
AYSHFYD
KIRVY
VWCPR
PV1-HAI01001
D1YSJ4
SMMATG
RFDME
KWDDYTWQT
FYTYG
AYSHFYD
KIRVY
VWCPR
PV1-DOR01012
D1YSJ5
SMMATG
RFDME
KWDDYTWQT
FYTYG
AYSHFYD
KIRVY
VWCPR
PV1-DOR01002C
D1YSJ6
SMMATG
RFDME
KWDDYTWQT
FYTYG
AYSHFYD
KIRVY
VWCPR
PV1-DOR01002
D1YSJ7
SMMATG
RFDME
KWDDYTWQT
FYTYG
AYSHFYD
KIRVY
VWCPR
PV1-DOR01001C1
D1YSJ9
SMMATG
RFDME
KWDDYTWQT
FYTYG
AYSHFYD
KIRVY
VWCPR
PV1-DOR00042C2
D1YSK1
SMMATG
RFDME
KWDDYTWQT
FYTYG
AYSHFYD
KIRVY
VWCPR
PV1-DOR00042C1
D1YSK2
SMMATG
RFDME
KWDDYTWQT
FYTYG
AYSHFYD
KIRVY
VWCPR
PV1-DOR00042
D1YSK3
SMMATG
RFDME
KWDDYTWQT
FYTYG
AYSHFYD
KIRVY
VWCPR
PV1-DOR00041C3
D1YSK4
SMMATG
RFDME
KWDDYTWQT
FYTYG
AYSHFYD
KIRVY
VWCPR
PV1-DOR00041C2
D1YSK5
SMMATG
RFDME
KWDDYTWQT
FYTYG
AYSHFYD
KIRVY
VWCPR
PV1-DOR00044
D1YSK6
SMMATG
RFDME
KWDDYTWQT
FYTYG
AYSHFYD
KIRVY
VWCPR
PV1-DOR00028C
D1YSK7
SMMATG
RFDME
KWDDYTWQT
FYTYG
AYSHFYD
KIRVY
VWCPR
PV1-DOR00028
D1YSK8
SMMATG
RFDME
KWDDYTWQT
FYTYG
AYSHFYD
KIRVY
VWCPR
PV1-DOR00023C
D1YSK9
SMMATG
RFDME
KWDDYTWQT
FYTYG
AYSHFYD
KIRVY
VWCPR
PV1-DOR00025
D1YSL0
SMMATG
RFDME
KWDDYTWQT
FYTYG
AYSHFYD
KIRVY
VWCPR
PV1-DOOR24
D1YSL1
SMMATG
RFDME
KWDDYTWQT
FYTYG
AYSHFYD
KIRVY
VWCPR
PV1-DOR00015
D1YSL2
SMMATG
RFDME
KWDDYTWQT
FYTYG
AYSHFYD
KIRVY
VWCPR
PV1-DOR00016
D1YSL3
SMMATG
RFDME
KWDDYTWQT
FYTYG
AYSHFYD
KIRVY
VWCPR
PV1-HAI01013all
D1YSL4
SMMATG
RFDME
KWDDYTWQT
FYTYG
AYSHFYD
KIRVY
VWCPR
PV1-HAI01015
D1YSL5
SMMATG
RFDME
KWDDYTWQT
FYTYG
AYSHFYD
KIRVY
VWCPR
PV1-S302
D2X673
SMMATG
RFDME
KWDDYTWQT
FYTYG
AYSHFYD
KIRVY
VWCPR
CHN8184/GZ/CHN/2004
D8L541
SMMATG
RFDME
KWDDYTWQT
FYTYG
AYSHFYD
KIRVY
VWCPR
PV3 isolated
B4YUL3
SMMATG
RFDME
sWDDYTWQT
FYTYG
AYSHFYD
KvRVY
VWCPR
PV3 isolated
B4YUL4
SMMATG
RFDME
sWDDYTWQT
FYTYG
AYSHFYD
KvRVY
VWCPR
PV3 (vacc.StrainSabin3 (Leon 12a1b))
Q84792
SMMATG
RFDME
sWDDYTWQT
FYTYG
AYSHFYD
KvRiY
VWCPR
PV3-33239
C5HJY2
SMMATG
RFDME
sWDDYTWQT
FYTYG
AYSHFYD
KvRiY
VWCPR
PV3-31974
C5HJY3
SMMATG
RFDME
sWDDYTWQT
FYTYG
AYSHFYD
KvRiY
VWCPR
PV3-FIN84-60212
D1GE40
SMMATG
RFDME
sWDDYTWQT
FYTYG
AYSHFYD
KvRiY
VWCPR
PV3-SWI10947
D2E679
SMMATG
RFDME
sWDDYTWQT
FYTYG
AYSHFYD
KvRiY
VWCPR
PV3-FIN84-2493
D1GE41
SMMATG
RFDME
sWDDYTWQT
FYTYG
AYSHFYD
KvRiY
VWCPR
PV3-P3/Jinan/1/09
D2XUS9
SMMATG
RFDME
sWDDYTWQT
FYTYG
AYSHFYD
KvRiY
VWCPR
The 43 PV sequences were aligned using ClustalW multialignment program (http://www.uniprot.org/align/) [24]. The analyzed PV sequences and related references are described at http://www.uniprot.org/ and reported by Swiss-Prot/UniProtKB accession number. Peptide sequences present in PV-derived epitopes (see Table 2) and absent in the human proteome were localized along the 43 aligned PV sequences and analyzed for conservativeness. Peptide sequences are indicated by their position along the PV polyprotein. Mutated aa residues are in lower case.