Table 3
Conservativeness of epitopic PV peptide regions among 43 PV strains and variants.
| | PV strain | UniProt/Swiss-Prot entry | aa Pos 464 | aa Pos 708 | aa Pos 748 | aa Pos 763 | aa Pos
783 | aa Pos 835 | aa Pos 847 |
| | PV1 Mahoney | P03300 | FMMATG | RFDME | KWDDYTWQT | FYTYG | AYSHFYD | KIRVY | VWCPR | | PV1 Sabin | P03301 | SMMATG | RFDME | KWDDYTWQT | FYTYG | AYSHFYD | KIRVY | VWCPR | | PV3 P3/Leon/37 | P03302 | SMMATG | RFDME | sWDDYTWQT | FYTYG | AYSHFYD | KvRiY | VWCPR | | PV3 23127 | P06209 | SMMATG | RFDME | sWDDYTWQT | FYTYG | AYSHFYD | KvRvY | VWCPR | | PV1 isolated | Q9Q281 | SMMATG | RFDME | KWDDYTWQT | FYTYG | AYSHFYD | KvRVY | VWCPR | | PV1 isolated | Q9Q280 | SMMATG | RFDME | KWDDYTWQT | FYTYG | AYSHFYD | KIRVY | VWCPR | | PV1 isolated | Q71AZ9 | SMMATG | RFDME | KWDDYTWQT | FYTYG | AYSHFYD | KIRVY | VWCPR | | PV1 isolated | Q5TLH5 | SMMATG | RFDME | KWDDYTWQT | FYTYG | AYSHFYD | KIRVY | VWCPR | | PV1-HAI01008C2 | D1YSI9 | SMMATG | RFDME | KWDDYTWQT | FYTYG | AYSHFYD | KIRVY | VWCPR | | PV1-HAI01009 | D1YSJ1 | SMMATG | RFDME | KWDDYTWQT | FYTYG | AYSHFYD | KIRVY | VWCPR | | PV1-HAI01008 | D1YSJ2 | SMMATG | RFDME | KWDDYTWQT | FYTYG | AYSHFYD | KIRVY | VWCPR | | PV1-HAI01002 | D1YSJ3 | SMMATG | RFDME | KWDDYTWQT | FYTYG | AYSHFYD | KIRVY | VWCPR | | PV1-HAI01001 | D1YSJ4 | SMMATG | RFDME | KWDDYTWQT | FYTYG | AYSHFYD | KIRVY | VWCPR | | PV1-DOR01012 | D1YSJ5 | SMMATG | RFDME | KWDDYTWQT | FYTYG | AYSHFYD | KIRVY | VWCPR | | PV1-DOR01002C | D1YSJ6 | SMMATG | RFDME | KWDDYTWQT | FYTYG | AYSHFYD | KIRVY | VWCPR | | PV1-DOR01002 | D1YSJ7 | SMMATG | RFDME | KWDDYTWQT | FYTYG | AYSHFYD | KIRVY | VWCPR | | PV1-DOR01001C1 | D1YSJ9 | SMMATG | RFDME | KWDDYTWQT | FYTYG | AYSHFYD | KIRVY | VWCPR | | PV1-DOR00042C2 | D1YSK1 | SMMATG | RFDME | KWDDYTWQT | FYTYG | AYSHFYD | KIRVY | VWCPR | | PV1-DOR00042C1 | D1YSK2 | SMMATG | RFDME | KWDDYTWQT | FYTYG | AYSHFYD | KIRVY | VWCPR | | PV1-DOR00042 | D1YSK3 | SMMATG | RFDME | KWDDYTWQT | FYTYG | AYSHFYD | KIRVY | VWCPR | | PV1-DOR00041C3 | D1YSK4 | SMMATG | RFDME | KWDDYTWQT | FYTYG | AYSHFYD | KIRVY | VWCPR | | PV1-DOR00041C2 | D1YSK5 | SMMATG | RFDME | KWDDYTWQT | FYTYG | AYSHFYD | KIRVY | VWCPR | | PV1-DOR00044 | D1YSK6 | SMMATG | RFDME | KWDDYTWQT | FYTYG | AYSHFYD | KIRVY | VWCPR | | PV1-DOR00028C | D1YSK7 | SMMATG | RFDME | KWDDYTWQT | FYTYG | AYSHFYD | KIRVY | VWCPR | | PV1-DOR00028 | D1YSK8 | SMMATG | RFDME | KWDDYTWQT | FYTYG | AYSHFYD | KIRVY | VWCPR | |
PV1-DOR00023C | D1YSK9 | SMMATG | RFDME | KWDDYTWQT | FYTYG | AYSHFYD | KIRVY | VWCPR | | PV1-DOR00025 | D1YSL0 | SMMATG | RFDME | KWDDYTWQT | FYTYG | AYSHFYD | KIRVY | VWCPR | | PV1-DOOR24 | D1YSL1 | SMMATG | RFDME | KWDDYTWQT | FYTYG | AYSHFYD | KIRVY | VWCPR | | PV1-DOR00015 | D1YSL2 | SMMATG | RFDME | KWDDYTWQT | FYTYG | AYSHFYD | KIRVY | VWCPR | | PV1-DOR00016 | D1YSL3 | SMMATG | RFDME | KWDDYTWQT | FYTYG | AYSHFYD | KIRVY | VWCPR | | PV1-HAI01013all | D1YSL4 | SMMATG | RFDME | KWDDYTWQT | FYTYG | AYSHFYD | KIRVY | VWCPR | | PV1-HAI01015 | D1YSL5 | SMMATG | RFDME | KWDDYTWQT | FYTYG | AYSHFYD | KIRVY | VWCPR | | PV1-S302 | D2X673 | SMMATG | RFDME | KWDDYTWQT | FYTYG | AYSHFYD | KIRVY | VWCPR | | CHN8184/GZ/CHN/2004 | D8L541 | SMMATG | RFDME | KWDDYTWQT | FYTYG | AYSHFYD | KIRVY | VWCPR | | PV3 isolated | B4YUL3 | SMMATG | RFDME | sWDDYTWQT | FYTYG | AYSHFYD | KvRVY | VWCPR | | PV3 isolated | B4YUL4 | SMMATG | RFDME | sWDDYTWQT | FYTYG | AYSHFYD | KvRVY | VWCPR | PV3 (vacc.StrainSabin3
(Leon 12a1b)) | Q84792 | SMMATG | RFDME | sWDDYTWQT | FYTYG | AYSHFYD | KvRiY | VWCPR | | PV3-33239 | C5HJY2 | SMMATG | RFDME | sWDDYTWQT | FYTYG | AYSHFYD | KvRiY | VWCPR | | PV3-31974 | C5HJY3 | SMMATG | RFDME | sWDDYTWQT | FYTYG | AYSHFYD | KvRiY | VWCPR | | PV3-FIN84-60212 | D1GE40 | SMMATG | RFDME | sWDDYTWQT | FYTYG | AYSHFYD | KvRiY | VWCPR | | PV3-SWI10947 | D2E679 | SMMATG | RFDME | sWDDYTWQT | FYTYG | AYSHFYD | KvRiY | VWCPR | | PV3-FIN84-2493 | D1GE41 | SMMATG | RFDME | sWDDYTWQT | FYTYG | AYSHFYD | KvRiY | VWCPR | | PV3-P3/Jinan/1/09 | D2XUS9 | SMMATG | RFDME | sWDDYTWQT | FYTYG | AYSHFYD | KvRiY | VWCPR |
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The 43 PV sequences were aligned using ClustalW multialignment program (http://www.uniprot.org/align/) [24]. The analyzed PV sequences and related references are described at http://www.uniprot.org/ and reported by Swiss-Prot/UniProtKB accession number. Peptide sequences present in PV-derived epitopes (see Table 2) and absent in the human proteome were localized along the 43 aligned PV sequences and analyzed for conservativeness. Peptide sequences are indicated by their position along the PV polyprotein. Mutated aa residues are in lower case.
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