Journal of Immunology Research / 2015 / Article / Tab 1

Research Article

Vitamin D Deficiency Contributes to the Reduction and Impaired Function of Naïve Regulatory T Cell in Chronic Heart Failure

Table 1

Characteristics of chronic heart failure patients and healthy donors.

HDChronic HFAcute myocardial infarction
NYHA IINYHA IIINYHA IV

3534331718
Gender (M/F)17/1820/1428/78/913/5
Age, mean ± SD years45.1 ± 11.677.7 ± 11.179.2 ± 9.478.1 ± 6.472.4 ± 14.8
HR (bmp)NA83 ± 2385 ± 1885 ± 1681 ± 16
LVEF (%)NA61.6 ± 9.659.4 ± 11.351.4 ± 11.952.5 ± 17.4
LVEDD (d/mm)NA52.0 ± 6.754.5 ± 9.355.6 ± 8.351.1 ± 4.1
HF risk factors, (%)
HyperlipemiaNA7 (20.6)6 (18.2)2 (11.8)2 (11.1)
 Diabetes mellitusNA16 (47.1)14 (42.4)5 (29.4)7 (38.9)
 Cigarette smoking
  Former smokerNA7 (20.6)6 (18.2)3 (17.6)3 (16.7)
  Current smokerNA4 (11.8)9 (27.3)1 (5.9)1 (5.6)
Disease etiology, (%)
 Coronary heart diseaseNA20 (58.8)22 (66.7)7 (41.2)11 (61.1)
 HypertensionNA22 (64.7)28 (84.8)7 (41.2)10 (55.6)
 CardiomyopathyNA2 (5.9)1 (3.0)2 (11.8)0 (0)
Biochemical cardiac markers
 25(OH)D (ng/mL)17.7 ± 6.913.4 ± 7.6**12.9 ± 9.3*10.3 ± 6.5***19.8 ± 7.9
 NT-ProBNP (pg/mL)NA2466 ± 23273994 ± 48863690 ± 30253591 ± 3691
Hcy (mmol/L)NA10.67 ± 0.9617.57 ± 3.7022.83 ± 6.5710.68 ± 1.52
hsCRP (ng/mL)0.39 ± 0.077.25 ± 0.86***9.13 ± 0.73***8.32 ± 0.93***10.31 ± 0.96***
 LDL (mmol/L)2.61 ± 0.111.92 ± 0.12**1.89 ± 0.12**1.77 ± 0.16**1.96 ± 0.27**
Lp(a) (mg/dL)6.34 ± 1.356.32 ± 0.929.95 ± 1.638.25 ± 2.1811.40 ± 2.26
Medications, (%)
 ACEI/ARBNA6 (17.6)12 (36.4)2 (11.8)3 (16.7)
β-blockersNA8 (23.5)9 (27.3)3 (17.6)5 (27.8)
 DigitalisNA4 (11.8)6 (18.2)7 (41.2)2 (11.1)
 DiureticsNA9 (26.5)9 (27.3)8 (47.1)4 (22.2)
 StatinsNA6 (17.6)6 (18.2)2 (11.8)6 (33.3)
 Ca2+-blockersNA6 (17.6)5 (15.2)1 (5.9)0 (0)

Except where indicated otherwise, values are the number (%). NA = not applicable. Data represent the mean ± SD. *, **, and *** compared to HD.

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