Liver expression of PXR and SULT2A1 in liver tissue from patients with cirrhotic PSC and PBC. (a) PXR mRNA, (b) PXR protein, (c) SULT2A1 mRNA, and (d) SULT2A1 protein. Levels of gene expression presented as fold-change relative to control were normalized with glyceraldehydes 3-phosphate dehydrogenase (GAPDH). Bars indicate the mean ± SEM. Changes in protein levels were determined by densitometry analyses after normalization to α/β tubulin as a control for loading. Bars indicate the mean ± SEM.