Familial Aggregation and Segregation Analysis in Families Presenting Autoimmunity, Polyautoimmunity, and Multiple Autoimmune Syndrome

Table 1

Characteristics of probands and families classified as late-onset and early-onset.

Characteristic	Late-onset				Early-onset
	All	AD	PolyAD	MAS	All	AD	PolyAD/MAS
Age (yrs)	49.43	45.99	45.49	44.81	32.32	19.54	16
Min, Max	11, 91	13, 83	16, 78	20, 64	3, 94	4, 70
Age at onset (yrs)	—	32.80	33.42	33.97	—	7.77	11
Min, Max		5, 62	5, 62	5, 62		1, 24
Male
Aff (Unaff)	265	24 (156)	8 (172)	2 (178)	227	50 (141)	0 (191)
Female
Aff (Unaff)	451	195 (216)	91 (320)	41 (370)	216	52 (152)	1 (203)
Number of Peds	127				83
Mean size ± SD	5.64 ± 2.76				5.34 ± 2.94
Min, Max	3, 16				3, 20

AD: autoimmune disease; PolyAD: polyautoimmunity; MAS: multiple autoimmune syndrome. Data correspond to FDRs affected or unaffected and taking into account the analysis. Aff: affected; Unaff: unaffected.
value < 0.001 -test when comparing late-onset versus early-onset variables.