The Association of the GABRP Polymorphisms with Systemic Lupus Erythematosus
Table 3
Genotype and allele analyses of the GABRP gene polymorphisms in the female SLE patients and female healthy controls.
Position
Genotype/allele
Control (%)
SLE (%)
Odds ratio (95% CI)
rs929763
TT
109 (56.8)
63 (42.6)
1.00
<0.0001
TA
73 (38.0)
56 (37.8)
1.33 (0.83–2.12)
AA
10 (5.2)
29 (19.6)
5.02 (2.29–10.98)
T
291 (75.8)
182 (61.5)
1.00
<0.0001
A
93 (24.2)
114 (38.5)
1.96 (1.410–2.73)
rs732157
CC
108 (54.8)
89 (59.3)
1.00
0.40
CT
76 (38.6)
52 (34.7)
0.83 (0.53–1.30)
TT
13 (6.6)
9 (6.0)
0.84 (0.34–2.06)
C
292 (74.1)
230 (76.7)
1.00
0.44
T
102 (25.9)
70 (23.3)
0.87 (0.61–1.24)
rs2303134
AA
193 (97.0)
150 (98.7)
1.00
0.29
AG
6 (3.0)
2 (1.3)
0.43 (0.09–2.16)
GG
0 (0)
0 (0)
—
A
392 (98.5)
302 (99.3)
1.00
0.29
G
6 (1.5)
2 (0.7)
0.43 (0.09–2.16)
rs1063310
CC
86 (43.9)
77 (51.7)
1.00
0.1
CA
95 (48.5)
59 (39.6)
0.69 (0.44–1.09)
AA
15 (7.6)
13 (8.7)
0.97 (0.43–2.16)
C
267 (68.1)
213 (71.5)
1.00
0.34
A
125 (31.9)
85 (28.5)
0.85 (0.61–1.19)
rs3805455
CC
89 (44.9)
60 (41.7)
1.00
0.005
CT
93 (47.0)
58 (40.3)
0.93 (0.58–1.47)
TT
16 (8.1)
26 (18.1)
2.41 (1.19–4.87)
C
271 (68.4)
178 (61.8)
1.00
0.07
T
125 (31.6)
110 (38.2)
1.34 (0.97–1.84)
rs3828619
GG
113 (57.4)
68 (48.9)
1.00
0.008
GA
71 (36.0)
50 (36.0)
1.17 (0.73–1.87)
AA
13 (6.6)
21 (15.1)
2.68 (1.26–5.71)
G
297 (75.4)
186 (66.9)
1.00
0.02
A
97 (24.6)
92 (33.1)
1.51 (1.08–2.13)
Calculated from the translation start site. Logistic regression analyses were used for calculating OR (95% CI; confidence interval). Value was determined by Fisher’s exact test or test from a 2 × 2 contingency table.
