The Pathogenicity of Anti-β2GP1-IgG Autoantibodies Depends on Fc Glycosylation

Figure 3

OD values of C3c (a) bound to anti-β2GP1 and OD values of anti-β2GP1-IgM (b) in sera of patients with APS and healthy children. Anti-β2GP1 of healthy children displayed significantly more bound C3c than that of patients with APS (). This suggests a more efficient clearance of β2GP1-immune complexes in the healthy children. Anti-β2GP1-IgM OD values of patients with APS were significantly higher than those of healthy children. Horizontal lines represent the median OD value of the cohort. APS = antiphospholipid syndrome; OD = optical density.

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