Autoimmune Hepatitis in Brazilian Children: IgE and Genetic Polymorphisms in Associated Genes

Table 5

Multivariate analysis of factors associated with AIH-1, using three different models.

	Dependent variable		OR	95% CI
	AIH-1
Model 1
HLA-DRB1	Different from 03 and/or 13	<0.001	8.28	3.46–19.82
	03 and/or 13
IL13 rs20541	AG plus GG	0.002	9.45	2.28–39.18
	AA
IL4RA rs1805011	AG plus GG	0.001	3.72	1.78–7.77
	AA
	IL5 rs2069812
Model 2
Treatment suspension	Yes	0.004	6.41	1.83–22.44
	No
	IgE levels
Model 3
IL4 rs2227284	TT and GT	0.022	7.42	1.33–41.34
	GG

Dependent variable in model 1: AIH-1 susceptibility.
Dependent variable in model 2: IL5 rs2069812.
Dependent variable in model 3: IgE levels.
IL13 codon 110 (rs20541): A allele = Q (glutamic acid) and G allele = R (arginine); IL4RA codon 50 (rs1805011): A allele = I (isoleucine) and G allele = V (valine).
Homozigosis for T allele.