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Journal of Immunology Research
Volume 2015, Article ID 680749, 12 pages
http://dx.doi.org/10.1155/2015/680749
Review Article

TRAIL Modulates the Immune System and Protects against the Development of Diabetes

1Department of Medical, Surgical, and Health Sciences, University of Trieste, Cattinara University Hospital, Strada di Fiume 447, 34100 Trieste, Italy
2Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Via dell’Istria 65, 34100 Trieste, Italy
3Department of Morphology, Surgery, and Experimental Medicine, LTTA Centre, University of Ferrara, Via Fossato di Mortara 66, 44100 Ferrara, Italy

Received 22 December 2014; Accepted 2 February 2015

Academic Editor: Kurt Blaser

Copyright © 2015 Fleur Bossi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

TRAIL or tumor necrosis factor (TNF) related apoptosis-inducing ligand is a member of the TNF superfamily of proteins, whose best characterized function is the induction of apoptosis in tumor, infected, or transformed cells through activation of specific receptors. In nontransformed cells, however, the actions of TRAIL are less well characterized. Recent studies suggest that TRAIL may be implicated in the development and progression of diabetes. Here we review TRAIL biological actions, its effects on the immune system, and how and to what extent it has been shown to protect against diabetes.