Research Article
Genetic Predictors of Poor Prognosis in Portuguese Patients with Juvenile Idiopathic Arthritis: Data from Reuma.pt
Table 1
Distribution of the clinical characteristics of patients with and without poor prognosis.
| | Variable | Total | Patients with poor prognosis | Patients without poor prognosis | value |
| | Number | 267 | 85 | 182 | | | Female gender (%) | 171 (64) | 60 (22.59) | 111 (41.6) | 0.166 | | JIA categories (%): | | | | | | Polyarticular RF negative | 48 (18) | 19 (39.6) | 29 (60.4) | <0.001 | | Polyarticular RF positive | 25 (9.4) | 19 (76) | 6 (24) | | Extended oligoarticular | 43 (16.1) | 17 (39.5) | 26 (60.5) | | Persistent oligoarticular | 89 (33.3) | 7 (7.9) | 82 (92.1) | | Systemic | 22 (8.2) | 11 (50) | 11 (50) | | Enthesitis-related arthritis | 28 (10.5) | 8 (28.6) | 20 (71.4) | | Psoriatic arthritis | 12 (4.5) | 4 (33.3) | 8 (66.7) | | Age at disease onset (median (IQR)) | 5.3 (2.2–9.7) | 6.6 (3.1–11.6) | 4.8 (2.1–8.8) | 0.056 | | Age at diagnosis (median (IQR)) | 6.6 (2.8–11.6) | 8.7 (3.4–13.7) | 5.7 (2.5–10.6) | 0.013 | | Time until diagnosis (median (IQR)) | 0.33 (1.14–1.00) | 0.50 (0.17–1.0) | 0.26 (0.14–0.88) | 0.130 | | Age at last visit (median (IQR)) | 14.3 (8.9–18.3) | 16.9 (13.1–24.1) | 12.7 (6.9–13.3) | <0.001 | | Disease duration (median (IQR)) | 6.4 (3.1–12.0) | 10.4 (5.2–16.0) | 4.9 (2.3–10.4) | <0.001 | | CHAQ/HAQ (median (IQR)) | 0 (0–0.25) | 0.25 (0-1) | 0 (0–0.13) | <0.001 | | Patient’s/parent’s VAS (median (IQR)) | 5 (0–30) | 10 (0–50) | 0 (0–30) | 0.017 | | Physician VAS (median (IQR)) | 0 (0–20) | 10 (0–35) | 0 (0–11.3) | <0.001 | | Extra-articular manifestations | 98 | 41 | 57 | 0.011 | | Duration of DMARD use (median (IQR)) | 2.37 (0–5.8) | 5.46 (3.02–9.54) | 1.43 (0–4.02) | <0.001 | | Corticosteroid use (Y/N) | 124 | 52 | 68 | <0.001 |
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F: female; M: male; JIA: juvenile idiopathic arthritis; RF: rheumatoid factor; IQR: interquartile range; CHAQ: Childhood Health Assessment Questionnaire; HAQ: Health Assessment Questionnaire; SD: standard deviation; VAS: visual analogue scale; DMARD: Disease Modifying Antirheumatic Drug; Y: yes; N: no. values < 0.05 were considered statistically significant. Note: values are from Pearson’s chi-squared or Mann-Whitney tests, as appropriate.
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