Uptake of CCR7 by KIR2DS4⁺ NK Cells Is Induced upon Recognition of Certain HLA-C Alleles

Figure 3

Comparison between KIR2DS4⁺ and KIR2DS4⁻ NK cell clones in the killing of transfected 221 cell lines. (a, b) The cytolytic activity of KIR2DS4⁻ NKG2A⁺ and KIR2DS4⁺ NKG2A⁺ NK cell clones (derived from a B haplotype donor) was analyzed against untransfected or Cw3-, Cw4-, or Cw6-transfected 221 cells in the absence or in the presence of mAbs to the indicated molecules. The ratio used was 1 : 1. The average of 4 independent experiments and standard deviation (mean ± SD) are indicated. ; .

(a)

(b)