Review Article
Contribution of Genetic Factors to Sjögren’s Syndrome and Sjögren’s Syndrome Related Lymphomagenesis
Table 1
Genetic associations of the HLA alleles with Sjögren’s syndrome susceptibility.
| | Study | Year | Population | Sample size (patients/controls) | Associated HLA alleles |
| |
Chused et al. [18] | 1977 | American Caucasian | 110 (19/91) | HLA-Dw3 | | Fye et al. [22] | 1978 | American Caucasian | 115 (19/96) | HLA-Dw3-HLA-B8 | | Moutsopoulos et al. [23] | 1978 | American Caucasian | 208 (24/184) | B lymphocytes immune response associated (Ia) antigens | | Moutsopoulos et al. [24] | 1979 | American Caucasian | 206 (22/184) | HLA-DRw3-HLA-B8 | | Manthorpe et al. [27] | 1981 | Danish | 32 (32/—) | HLA-Dw2 | | Mann and Moutsopoulos [25] | 1983 | American Caucasian | 52 (25/27) | HLA-DRw3-HLA-B8 | | Molina et al. [28] | 1986 | American Caucasian | 694 (68/626) | HLA-B8
HLA-DR3
DRw52 | | Moriuchi et al. [29] | 1986 | Japanese | 135 (21/114) | DRw53 | | Vitali et al. [30] | 1986 | Italian | 90 (28/62) | DR3 | | Papasteriades et al. [26] | 1988 | Greek | 218 (46/172) | DR-5 | | Pease et al. [31] | 1989 | British
Caucasian | 141 (41/100) | DR-3
DRw52 | | Morling et al. [41] | 1991 | Danish | 19 (19/—) | DQA10501-DQB10201-DQA10301 | | Kang et al. [36] | 1993 | American Caucasian | 210 (75/135) | DRB103-DRB30101-DQB10201-DQA10501 | | Kang et al. [36] | 1993 | Chinese | 87 (45/42) | DRB10803-DQA10103-DQB10601 | | Kang et al. [36] | 1993 | Japanese | 82 (33/49) | DRB10405-DRB40101-DQA10301-DQB10401 | | Roitberg-Tambur et al. [43] | 1993 | Jews (Israel) | 275 (17/258) | DQA1001-DQA10201-DQB10501 | | Roitberg-Tambur et al. [43] | 1993 | Greek | 76 (22/54) | DQA10501 | | Portales et al. [42] | 1994 | Spanish | 286 (30/256) | HLA-Cw7
DR3
DR11 | | Wang et al. [32] | 1997 | Chinese | 206 (70/136) | DR3, DR52, DR2, DR5, and DR9 | | Jean et al. [38] | 1998 | French | 242 (42/200) | DRBI1501-0301-DQB10201-0602 | | Rishmueller et al. [33] | 1998 | Australian | 244 (80/164) | DR3-DQA10501-DQB102 | | Bolstad et al. [34] | 2001 | Norwegian Caucasian | 95 (31/64) | DRB103-DQB102-DQA10501 | | Nakken et al. [40] | 2001 | Norwegian Caucasian | 210 (29/181) | DRB10301 | | Anaya et al. [39] | 2002 | Colombian | 149 (73/76) | DRB10301 | | Gottenberg et al. [35] | 2003 | French | 371 (149/222) | DRB103 | | Manoussakis et al. [44] | 2004 | Greek | 301 (55/246) | DRB10301 | | Kovács et al. [37] | 2006 | Hungarian | 98 (48/50) | DQB10201-DRB103-DQB10501 | | Cruz-Tapias et al. [21] | 2012 | Meta-analysis | 7636 (1166/6470) | DQA10501-DQB10201-DRB10301-DQA10201-DQA10301-DQB10501 | | Li et al. [46] | 2013 | Chinese | 5622 (1845/3777) | HLA class II locus | | Lessard et al. [45] | 2013 | Caucasian | 10916 (4712/6204) | HLA class II locus |
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