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Journal of Immunology Research
Volume 2015, Article ID 761820, 13 pages
http://dx.doi.org/10.1155/2015/761820
Review Article

Peptide-Based Treatment: A Promising Cancer Therapy

Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China

Received 26 September 2014; Accepted 14 December 2014

Academic Editor: Masha Fridkis-Hareli

Copyright © 2015 Yu-Feng Xiao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Many new therapies are currently being used to treat cancer. Among these new methods, chemotherapy based on peptides has been of great interest due to the unique advantages of peptides, such as a low molecular weight, the ability to specifically target tumor cells, and low toxicity in normal tissues. In treating cancer, peptide-based chemotherapy can be mainly divided into three types, peptide-alone therapy, peptide vaccines, and peptide-conjugated nanomaterials. Peptide-alone therapy may specifically enhance the immune system’s response to kill tumor cells. Peptide-based vaccines have been used in advanced cancers to improve patients’ overall survival. Additionally, the combination of peptides with nanomaterials expands the therapeutic ability of peptides to treat cancer by enhancing drug delivery and sensitivity. In this review, we mainly focus on the new advances in the application of peptides in treating cancer in recent years, including diagnosis, treatment, and prognosis.