Comparative Immunogenicity in Rabbits of the Polypeptides Encoded by the 5′ Terminus of Hepatitis C Virus RNA

Figure 3

Fine epitope mapping of antibody response to linear epitopes of HCV core (a) and F-protein (b) recognized by rabbits immunized with HCV core aa 1–173 (nn 93, 94), HCV core 1–152 (89/4, 90/5), and F-protein (91, 92). Graphs demonstrate the highest antibody titers reached throughout immunization and represent the result of two to three independent ELISA runs. Unspecific antipeptide reactivity in control rabbits receiving adjuvant alone was below 5 × 10².

(a)

(b)