Review Article
Pros and Cons of Antigen-Presenting Cell Targeted Tumor Vaccines
Table 1
Concise overview of the ontogenic, phenotypic, and functional features of the five main DC subtypes: cDC1, cDC2, pDC, LC, and moDC.
| | | cDC1 | cDC2 | pDC | LC | moDC |
| | Ontogeny | HSC + Flt3-L, BATF3, NFIL3, and Id2 | HSC + Flt3-L, RelB, NOTCH2, RBP-J, IRF2, and IRF4 | HSC + Flt3-L and E2-2 | Blood residing monocytes + inflammation | Fetal liver monocytes + CSF1R |
| Mouse
Other markers | CD8α+/CD103+ cDC
DEC205+ | CD4+ CD11b+ cDC | SiglecH+ BST2+ pDC
B220+ | Langerin+ LC | CD11b+ moDCs
CD64, FcγRε, and Ly6c |
| Human
Other markers | CD141+cDC
CD16 DEC20 | CD1c+cDC
CD11 | CD123+ pDC
BDCA-2+, BDCA-4+ | Langerin+ LC
DEC205, CD1 | CD11b+ CD1a+ moDCs
CD24+, CD206+, CD16+, and DC-SIGN |
| | Conserved (besides CD11c and MHC class II) | TLR3+ CADM1+ XCR1+ CLEC9A+ | MHCI SIRPα+ | TLR TLR | E-cadherin+, EpCAM+, and langerin+ | CD11b+ |
| | Functions | TH1
Cross-presentation | TH2 and TH17
Cross-presentation | IFN-α/β and IFNλ Humoral | Adaptable
MOUSE: Treg or TH17
HUMAN: IL-15 promoting CTLs + Cross-presentation | Highly adaptable
(IL-12, IL-23, TNFα, and iNOS) |
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