The Novel Functions of the PLC/PKC/PKD Signaling Axis in G Protein-Coupled Receptor-Mediated Chemotaxis of Neutrophils

Figure 1

PLC isoforms and their signaling pathways in neutrophils. (a) F-actin-based protrusion in the leading edge and myosin-based contraction in the trailing edge of chemotaxing neutrophil cell. (b) Scheme shows the domain compositions of PLC isoforms expressed in neutrophils. Scheme shows the PH domain, EF-hand motifs, catalytic X and Y domains, and C2 domain in all PLC isoforms. In addition to the domains indicated above, PLCγ2 is characterized by the insertion of a highly structured region (PLCγ-specific array, γSA), which is comprised of a split PH domain flanking two tandem SH2 domains and an SH3 domain between the two halves of a TIM-barrel catalytic domain. (c) Signaling pathways which activate PLC isoforms in neutrophils.

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