Immune Homeostasis in Epithelial Cells: Evidence and Role of Inflammasome Signaling Reviewed

Figure 2

Schematic representation of stratified squamous epithelium of the skin and oral mucosa. Toxic molecules and environmental and cellular stressors as well as microbial antigens can individually activate one or more inflammasome subtypes, leading to caspase-1 activation and the release of IL-1β, IL-18, bFGF, and HMGB1.