Effect of Leflunomide on the Abnormal Expression of Lipid Rafts and F-Actin in B Lymphocytes from Patients with Systemic Lupus Erythematosus

Figure 3

A771726 treatment altered the lipid rafts and F-actin expression in B cells in vitro. (a) Expression of lipid rafts on SLE B cells before and after A771726 treatment was analyzed by flow cytometry. A771726 treatment significantly reduced the lipid rafts expression level in SLE B cells. (b) Confocal microscopic profiles of B cells from 3 SLE patients show the modified lipid rafts and F-actin expression patterns after A771726 treatment. Magnification used was ×40 objective.

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