Review Article

Trans-Species Polymorphism in Immune Genes: General Pattern or MHC-Restricted Phenomenon?

Table 1

Number of published research articles dealing with TSP in vertebrate immune genes available on Web of Science, final update 19 March 2015. For details see Supplement 1.

Gene groupGeneNumber of references

Major histocompatibility complex (MHC)Classical MHC I: HLA-A, -B, -C, MHC Ia undifferentiated27
Non-classical MHC I: HLA-E, -G2
MHC IIA: DPA, DRA, DQA, DAA, MHC IIA undifferentiated36
MHC IIB: DPB, DRB, DQB, DAB, DRB-like, MHC IIB undifferentiated80

Non-MHC immunoglobulinsPSMB8 (LMP7)4
IGVH2
C Alfa gene2

Host defence peptidesAvBD122

2-5A synthetase familyOAS1b2

Tripartite motif protein familyTRIM5alfa2