Viral Interference and Persistence in Mosquito-Borne Flaviviruses

Table 2

Superinfections with flaviviruses in mosquito cell lines.

Cell line	Primary virus	Secondary virus	Type of interference	References
C6/36	DENV-1, DENV-2, DENV-3, or DENV-4	DENV-1, DENV-2, DENV-3, or DENV-4	Heterotypic	[31]
C6/36	DENV-1, DENV-2, DENV-3, or DENV-4; sylvatic and endemic strains	DENV-1, DENV-2, DENV-3, or DENV-4; sylvatic and endemic strains	Heterotypic	[43]
C6/36	DENV-2	DENV-2	None	[42]
C6/36	DENV-2	DENV-4	Heterotypic	[42]
C6/36	DENV-4	DENV-4	None	[42]
C6/36	DENV-4	DENV-2	None	[42]
C6/36	PCV	WNV or MVEV	Homologous	[12]
C6/36	CxFV	WNV	None	[45]
C6/36	NHUV	WNV or JEV or SLEV	Homologous	[48]
C6/36	DENV-2 and Aal DNV	JEV	None	[44]
C6/36	CxFV	WNV	Homologous	[47]
C6/36	DENV-1	DENV-3	Heterotypic	[30]
C6/36	DENV-3	DENV-1	Heterotypic	[30]
C6/36	DENV-1, DENV-2, DENV-3, or DENV-4	CHIKV	None	[31]
C6/36	DENV-3	CHIKV	None	[46]
C6/36	DENV-2	Aal DNV	None	[23]
C6/36	SINV	YFV	None	[35]
Sf9	SLEV	Baculovirus	None	[49]
C7-10	SINV	YFV	None	[35]
U4.4	SINV	YFV	None	[35]
Ae. albopictus cells	SINV	WNV	None	[29]
C6/36	DENV-4 or SINV	DENV-4 or SINV	Heterologous	[41]
C6/36	Aal DNV	DENV-2	Heterologous	[39]
TRA-171	DENV	VSV	Heterologous	[32]

Ae. albopictus, Aedes albopictus; DENV, Dengue virus; PCV, Palm Creek virus; WNV, West Nile virus; MVEV, Murray Valley encephalitis virus; JEV, Japanese encephalitis virus; SLEV, Saint Louis encephalitis virus; CHIKV, Chikungunya virus; CxFV, Culex flavivirus; NHUV, Nhumirim virus; Aal DNV, Aedes albopictus densovirus; SINV, Sindbis virus; YFV, Yellow fever virus; VSV, vesicular stomatitis virus.