Death Receptor 3 (TNFRSF25) Increases Mineral Apposition by Osteoblasts and Region Specific New Bone Formation in the Axial Skeleton of Male DBA/1 Mice
Effect of DR3 on OB-derived RANKL and OPG. (a) Cell surface expression of RANKL was analyzed on DR- and DR-derived OPCs and OB by flow cytometry. Both DR and DR OPCs displayed a 3-fold increase in RANKL signal over isotype control. RANKL signal increased to 5-fold over isotype in DR and DR OB. (b) Levels of soluble OPG were measured in culture supernatants by ELISA (DR , DR ). Expression of OPG was significantly elevated in the DR compared to DR OB cultures over the 26-day time course ().
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