Serum CEACAM1 Elevation Correlates with Melanoma Progression and Failure to Respond to Adoptive Cell Transfer Immunotherapy

Figure 2

sCEACAM1 sensitively reflects tumor excision and recurrence in mice. 20 SCID-NOD mice were subjected to subcutaneous injection of 009mel cells. When tumors reached ~500 mm³, they were excised from half of the mice in a complete ((a), ) or partial ((b)-(c), ) manner while the other mice underwent sham surgery ((d), ). In some of the mice recurrence of tumor occurred ((c), ). sCEACAM1 levels (depicted by a solid line) as well as tumors volumes (gray bars) were periodically measured and plotted against time. The arrow denotes the excision time point. The experiment was repeated two independent times. Shown are results from one representative mouse from each group.

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