Research Article
High Prevalence of Neutrophil Cytoplasmic Autoantibodies in Infants with Food Protein-Induced Proctitis/Proctocolitis: Autoimmunity Involvement?
Table 5
Major features of the 25 infants with Food protein-induced proctitis/proctocolitis.
| | Patient (sex) | Age month | Diet | dg. parents | a-pANCA IgG
IIF | a-pANCA IgA
IIF | ANA IgG
IIF | ANCA profile
ELISA | ASCA
IIF | a-EMA
IgA | a-EMA
IgG | a-tTg
IgA | a-tTg
IgG | Prick tests
cow’s milk
egg | Phadiatop
MJ/mL | FX5
MJ/mL | Calprotectin
ng/mL
<3000 ng/mL |
| | 1 (M) | 6 | Milk hydrolyzate | — | Positive | Neg. | Neg. | Neg. | Neg. | — | — | 1 | 1 | Negative | — | <0.35 | — | | 2 (F) | 2 | Breastfeeding | Mother IA | Highly positive | Positive | Neg. | Neg. | Neg. | Neg. | Neg. |
0.5 | 1 | Negative | — | <0.35 | 390 | | 3 (F) | 5 | Milk hydrolyzate | Mother IA | Highly positive | Neg. | Neg. | Neg. | Neg. | — | — | — | — | Negative | <0.35 | <0.35 | 339 | | 4 (M) | 2 | Breastfeeding | Mother IA | Highly positive | Neg. | Neg. | Positive
ELAST. | Neg. | — | — | — | — | Negative | <0.35 | <0.35 | 511 | | 5 (F) | 7 | Milk hydrolyzate | — | Highly positive | Neg. | Positive (granular) | Neg. | Neg. | — | — | — | — | Negative | — | — | 4286 | | 6 (F) | 24 | Egg-free diet | Mother IA | Positive | Neg. | Neg. | Neg. | Neg. | Neg. | Neg. | 1.2 | 1 | Negative | 2.22 | <0.35 | 4451 | | 7 (F) | 1 | Breastfeeding | — | Positive | Neg. | Neg. | Weakly positive PR3 | Neg. | Neg. | Neg. | 0.5 | 0.9 | Negative | <0.35 | <0.35 | 677 | | 8 (M) | 1 | Breastfeeding | Father IA | Weakly positive | Neg. | Neg. | Neg. | Neg. | — | — | — | — | Negative | | <0.35 | 385 | | 9 (M) | 24 | — | Mother IA | Positive | Neg. | Neg. | Neg. | Neg. | — | — | — | — | Negative | <0.35 | <0.35 | — | | 10 (M) | 2 | Breastfeeding | — | Positive | Neg. | Neg. | Neg. | Neg. | — | — | — | — | Negative | — | — | — | | 11 (M) | 3 | Breastfeeding | Mother, father IA | Positive | Neg. | Neg. | Neg. | Neg. | — | — | — | — | Negative | — | <0.35 | 83 | | 12 (F) | 24 | | Mother IA, FA | Weakly positive | Neg. | Neg. | Neg. | Neg. | Neg. | Neg. | 1.1 | 1 | Negative | <0.35 | <0.35 | 620 | | 13 (F) | 7 | Milk hydrolyzate | Mother IA, FA | Positive | Neg. | Neg. | Neg. | Neg. | — | — | — | — | Negative | <0.35 | <0.35 | 376 | | 14 (M) | 23 | — | — | Positive | Highly positive | Neg. | Weakly positive
PR3 | Neg. | Neg. | Neg. | 2.69 | 1.1 | Negative | — | <0.35 | 641 | | 15 (F) | 24 | — | Mother IA | Positive | Positive | Neg. | Positive
ELAST. | Neg. | Neg. | Neg. | 1 | 1.2 | Negative | <0.35 | <0.35 | 1014 | | 16 (M) | 4 | Milk hydrolyzate | — | Positive | Neg. | Neg. | Neg. | Neg. | — | — | 1.1 | 1.1 | Negative | <0.35 | <0.35 | 510 | | 17 (F) | 18 | Egg-free diet | Father IA | Positive | Neg. | Neg. | Neg. | Neg. | — | — | 1.1 | 1.2 | Negative | — | — | 548 | | 18 (M) | 15 | — | Father IA | Neg. | Positive | Neg. | Neg. | Neg. | Neg. | Neg. | 1.1 | 1 | Negative | <0.35 | <0.35 | 1270 | | 19 (F) | 18 | — | Mother celiakie | Highly positive | Neg. | Neg. | Neg. | Neg. | Neg. | Neg. | 1 | 1 | Negative | <0.35 | <0.35 | 1784 | | 20 (F) | 6 | Milk hydrolyzate | — | Highly positive | Highly positive | Neg. | Neg. | Neg. | Neg. | Neg. | 1 | 1.1 | Negative | — | — | 821 | | 21 (F) | 4 | Milk hydrolyzate | Father IA | Positive | Neg. | Neg. | Neg. | Neg. | Neg. | Neg. | 0.5 | 1.9 | Negative | <0.35 | 0.97 | 340 | | 22 (M) | 6 | Milk hydrolyzate | Father ulcerative colitis | Positive | Neg. | Neg. | Neg. | Neg. | — | — | — | — | Negative | — | >100 | 443 | | 23 (M) | 15 | Egg-free diet | — | Positive | Neg. | Neg. | Neg. | Neg. | — | — | — | — | Negative | — | — | 952 | | 24 (F) | 1 | Breastfeeding | — | Highly positive | Neg. | Neg. | Neg. | Neg. | — | — | — | — | Negative | <0.35 | — | 454 | | 25 (M) | 1 | Breastfeeding | Father IA | Weakly positive | Neg. | Neg. | Neg. | Neg. | — | — | — | — | Negative | <0.35 | <0.35 | 980 |
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IA: inhalation allergy.
FA: food allergy.
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