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Journal of Immunology Research
Volume 2015, Article ID 906086, 6 pages
http://dx.doi.org/10.1155/2015/906086
Research Article

Cyclic AMP-Responsive Element Modulator α Polymorphisms Are Potential Genetic Risks for Systemic Lupus Erythematosus

Department of Rheumatology & Immunology, Peking University People’s Hospital, 11 Xizhimen South Street, Beijing 100044, China

Received 17 June 2015; Revised 23 September 2015; Accepted 5 October 2015

Academic Editor: Fulvia Ceccarelli

Copyright © 2015 Qian Guo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

To investigate whether the cyclic AMP-responsive element modulator α (CREMα) polymorphisms are novel susceptibility factors for systemic lupus erythematosus (SLE), four tag SNPs, rs1057108, rs2295415, rs11592925, and rs1148247, were genotyped in 889 SLE cases and 825 healthy controls. Association analyses were performed on whole dataset or clinical/serologic subsets. Association statistics were calculated by age and sex adjusted logistic regression. The G allele frequencies of rs2295415 and rs1057108 were increased in SLE patients, compared with healthy controls (rs2295415: 21.2% versus 17.8%, OR 1.244, ; rs1057108: 30.8% versus 27.7%, OR 1.165, ). The haplotype constituted by the two risk alleles “G-G” from rs1057108 and rs2295415 displayed strong association with SLE susceptibility (OR 1.454, ). Following stratification by clinical/serologic features, a suggestive association was observed between rs2295415 and anti-Sm antibodies-positive SLE (OR 1.382, ). Interestingly, a potential protective effect of rs2295415 was observed for SLE patients with renal disorder (OR 0.745, ). Our data provide first evidence that CREMα SNPs rs2295415 and rs1057108 maybe novel genetic susceptibility factors for SLE. SNP rs2295415 appears to confer higher risk to develop anti-Sm antibodies-positive SLE and may play a protective role against lupus nephritis.