(a) Week 4 (observed data)
(b) Week 16 (LOCF)
(c) Week 24 (LOCF)
Figure 2: Changes in biomarkers with placebo, apremilast 20 mg BID, and apremilast 30 mg BID over Weeks 0 to 24. versus placebo (rank analysis of covariance two-sided value). . SEM: standard error mean.