Journal of Immunology Research / 2015 / Article / Tab 2

Research Article

Assessment of Physicochemical Properties of Rituximab Related to Its Immunomodulatory Activity

Table 2

Glycosylation microheterogeneity obtained by HILI-UPLC. Variation is presented as confidence interval at 95% ( = 3).

ProductBatchNonfucosylated (%)Hybrid (%)Sialylated (%)Galactosylated (%)High mannose (%)

MabTheraH06051.81 ± 0.045.00 ± 0.320.72 ± 0.0843.34 ± 1.424.37 ± 0.42
N35181.69 ± 0.113.48 ± 0.240.98 ± 0.2246.21 ± 1.543.19 ± 0.54
B622221.89 ± 0.112.91 ± 0.180.82 ± 0.1245.58 ± 0.473.03 ± 0.17

Kikuzubam54451306080.65 ± 0.212.72 ± 0.390.80 ± 0.2157.08 ± 8.523.25 ± 0.43
54451312160.65 ± 0.212.80 ± 0.080.71 ± 0.1356.35 ± 0.643.31 ± 0.16
54451310150.67 ± 0.053.19 ± 0.250.77 ± 0.1354.26 ± 3.023.51 ± 0.23

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