Meta-Analysis: Diagnostic Accuracy of Anti-Cyclic Citrullinated Peptide Antibody for Juvenile Idiopathic Arthritis

Figure 4

Hierarchical summary receiver operating characteristic (HSROC) curves of anti-CCP antibody assay for the diagnosis of JIA among all included studies (a) and RF+ PA subtype subgroup (b), together with the summary receiver operating characteristic (SROC) curve (solid line) and the bivariate summary estimate (solid square), with the corresponding 95% prediction ellipse (outer dotted line) and 95% confidence ellipse (inner dashed line). The symbol size for each study is proportional to the study size. The bivariate analysis presents studies as sensitivity and specificity data, which are identified by the coordinates of corresponding points in sensitivity-specificity space. Ellipses indicate the bidimensional limits of confidence of sensitivity and specificity for each diagnostic criterion: solid line, hsROC curve; square, bivariate summary estimate; dashed line, 95% confidence area; dotted line, 95% prediction area.

(a)

(b)