Table of Contents Author Guidelines Submit a Manuscript
Journal of Immunology Research
Volume 2015, Article ID 915276, 12 pages
http://dx.doi.org/10.1155/2015/915276
Review Article

Meta-Analysis: Diagnostic Accuracy of Anti-Cyclic Citrullinated Peptide Antibody for Juvenile Idiopathic Arthritis

1Department of Laboratory Medicine, General Hospital of Jinan Military Area, Jinan, Shandong 250031, China
2Department of Laboratory Medicine, Jinan Central Hospital, Jinan, Shandong 250013, China
3Division of Chest Disease, The Fourth Hospital of Jinan, Jinan, Shandong 250031, China

Received 14 November 2014; Accepted 1 February 2015

Academic Editor: Jacek Tabarkiewicz

Copyright © 2015 Yan Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. V. Ramanan and A. A. Grom, “Does systemic-onset juvenile idiopathic arthritis belong under juvenile idiopathic arthritis?” Rheumatology (Oxford), vol. 44, no. 11, pp. 1350–1353, 2005. View at Publisher · View at Google Scholar · View at Scopus
  2. K. Minden, M. Niewerth, J. Listing et al., “Long-term outcome in patients with juvenile idiopathic arthritis,” Arthritis and Rheumatism, vol. 46, no. 9, pp. 2392–2401, 2002. View at Publisher · View at Google Scholar · View at Scopus
  3. M. Zak and F. K. Pedersen, “Juvenile chronic arthritis into adulthood: a long-term follow-up study,” Rheumatology, vol. 39, no. 2, pp. 198–204, 2000. View at Publisher · View at Google Scholar · View at Scopus
  4. J. C. Packham, M. A. Hall, and T. J. Pimm, “Long-term follow-up of 246 adults with juvenile idiopathic arthritis: predictive factors for mood and pain,” Rheumatology, vol. 41, no. 12, pp. 1444–1449, 2002. View at Publisher · View at Google Scholar · View at Scopus
  5. J. M. Lawrence III, T. L. Moore, T. G. Osborn, G. Nesher, K. L. Madson, and M. B. Kinsella, “Autoantibody studies in juvenile rheumatoid arthritis,” Seminars in Arthritis and Rheumatism, vol. 22, no. 4, pp. 265–274, 1993. View at Publisher · View at Google Scholar · View at Scopus
  6. E. D. Ferucci, D. S. Majka, L. A. Parrish et al., “Antibodies against cyclic citrullinated peptide are associated with HLA-DR4 in simplex and multiplex polyarticular-onset juvenile rheumatoid arthritis,” Arthritis and Rheumatism, vol. 52, no. 1, pp. 239–246, 2005. View at Publisher · View at Google Scholar · View at Scopus
  7. D. J. Lovell, “Update on treatment of arthritis in children: new treatments, new goals,” Bulletin of the NYU Hospital for Joint Diseases, vol. 64, no. 1-2, pp. 72–76, 2006. View at Google Scholar · View at Scopus
  8. P. Woo and L. R. Wedderburn, “Juvenile chronic arthritis,” The Lancet, vol. 351, no. 9107, pp. 969–973, 1998. View at Publisher · View at Google Scholar · View at Scopus
  9. M. A. M. van Boekel, E. R. Vossenaar, F. H. J. van den Hoogen, and W. J. van Venrooij, “Autoantibody systems in rheumatoid arthritis: specificity, sensitivity and diagnostic value,” Arthritis Research, vol. 4, no. 2, pp. 87–93, 2002. View at Publisher · View at Google Scholar · View at Scopus
  10. R. Schneider and M. H. Passo, “Juvenile rheumatoid arthritis,” Rheumatic Disease Clinics of North America, vol. 28, no. 3, pp. 503–530, 2002. View at Publisher · View at Google Scholar · View at Scopus
  11. Y. El-Gamal, E. Hossny, R. Mabrouk, and T. El-Gamasey, “Antiperinuclear factor in the diagnosis of juvenile rheumatoid arthritis,” Pediatric Allergy and Immunology, vol. 6, no. 3, pp. 165–169, 1995. View at Publisher · View at Google Scholar · View at Scopus
  12. C. Gabay, A.-M. Prieur, and O. Meyer, “Occurrence of antiperinuclear, antikeratin, and anti-RA 33 antibodies in juvenile chronic arthritis,” Annals of the Rheumatic Diseases, vol. 52, no. 11, pp. 785–789, 1993. View at Publisher · View at Google Scholar · View at Scopus
  13. T. Avčin, R. Cimaz, F. Falcini et al., “Prevalence and clinical significance of anti-cyclic citrullinated peptide antibodies in juvenile idiopathic arthritis,” Annals of the Rheumatic Diseases, vol. 61, no. 7, pp. 608–611, 2002. View at Publisher · View at Google Scholar · View at Scopus
  14. G. Nesher, T. L. Moore, M. W. Grisanti, E. El-Najdawi, and T. G. Osborn, “Antiperinuclear factor in juvenile rheumatoid arthritis,” Annals of the Rheumatic Diseases, vol. 51, no. 3, pp. 350–352, 1992. View at Publisher · View at Google Scholar · View at Scopus
  15. D. Aletaha, T. Neogi, A. J. Silman et al., “2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative,” Arthritis & Rheumatism, vol. 62, no. 9, pp. 2569–2581, 2010. View at Publisher · View at Google Scholar
  16. K. Nishimura, D. Sugiyama, Y. Kogata et al., “Meta-analysis: diagnostic accuracy of anti-cyclic citrullinated peptide antibody and rheumatoid factor for rheumatoid arthritis,” Annals of Internal Medicine, vol. 146, no. 11, pp. 797–808, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. J. P. Riedemann, S. Muñoz, and A. Kavanaugh, “The use of second generation anti-CCP antibody (anti-CCP2) testing in rheumatoid arthritis—a systematic review,” Clinical and Experimental Rheumatology, vol. 23, no. 5, pp. S69–S76, 2005. View at Google Scholar · View at Scopus
  18. J. Sun, Y. Zhang, L. Liu, and G. Liu, “Diagnostic accuracy of combined tests of anti cyclic citrullinated peptide antibody and rheumatoid factor for rheumatoid arthritis: a meta-analysis,” Clinical and Experimental Rheumatology, vol. 32, no. 1, pp. 11–21, 2014. View at Google Scholar · View at Scopus
  19. P. Taylor, J. Gartemann, J. Hsieh, and J. Creeden, “A systematic review of serum biomarkers anti-cyclic citrullinated Peptide and rheumatoid factor as tests for rheumatoid arthritis,” Autoimmune Diseases, vol. 2011, Article ID 815038, 18 pages, 2011. View at Publisher · View at Google Scholar · View at Scopus
  20. B. E. Gilliam, A. K. Chauhan, J. M. Low, and T. L. Moore, “Measurement of biomarkers in juvenile idiopathic arthritis patients and their significant association with disease severity: a comparative study,” Clinical and Experimental Rheumatology, vol. 26, no. 3, pp. 492–497, 2008. View at Google Scholar · View at Scopus
  21. M. van Rossum, R. van Soesbergen, S. de Kort et al., “Anti-cyclic citrullinated peptide (anti-CCP) antibodies in children with juvenile idiopathic arthritis,” Journal of Rheumatology, vol. 30, no. 4, pp. 825–828, 2003. View at Google Scholar · View at Scopus
  22. J. S. Y. Kwok, K. H. Hui, T. L. Lee et al., “Anti-cyclic citrullinated peptide: diagnostic and prognostic values in juvenile idiopathic arthritis and rheumatoid arthritis in a Chinese population,” Scandinavian Journal of Rheumatology, vol. 34, no. 5, pp. 359–366, 2005. View at Publisher · View at Google Scholar · View at Scopus
  23. S. H. Machado, C. A. Von Mühlen, J. C. T. Brenol, L. Bisotto, and R. M. Xavier, “The prevalence of anti-cyclic citrullinated peptide antibodies in juvenile idiopathic arthritis,” Jornal de Pediatria, vol. 81, no. 6, pp. 491–494, 2005. View at Publisher · View at Google Scholar · View at Scopus
  24. J. M. Low, A. K. Chauhan, D. A. Kietz, U. Daud, P. H. Pepmueller, and T. L. Moore, “Determination of anti-cyclic citrullinated peptide antibodies in the sera of patients with juvenile idiopathic arthritis,” Journal of Rheumatology, vol. 31, no. 9, pp. 1829–1833, 2004. View at Google Scholar · View at Scopus
  25. Ö. Kasapçopur, S. Altun, M. Aslan et al., “Diagnostic accuracy of anti-cyclic citrullinated peptide antibodies in juvenile idiopathic arthritis,” Annals of the Rheumatic Diseases, vol. 63, no. 12, pp. 1687–1689, 2004. View at Publisher · View at Google Scholar · View at Scopus
  26. J. K. H. Brunner and F. C. Sitzmann, “Anticyclic citrullinated peptide antibodies in juvenile idiopathic arthritis,” Modern Rheumatology, vol. 16, no. 6, pp. 372–375, 2006. View at Publisher · View at Google Scholar · View at Scopus
  27. R. Gupta, M. M. Thabah, B. Vaidya, S. Gupta, R. Lodha, and S. K. Kabra, “Anti-cyclic citrullinated peptide antibodies in juvenile idiopathic arthritis,” Indian Journal of Pediatrics, vol. 77, no. 1, pp. 41–44, 2010. View at Publisher · View at Google Scholar · View at Scopus
  28. H. M. Habib, Y. M. Mosaad, and H. M. Youssef, “Anti-cyclic citrullinated peptide antibodies in patients with juvenile idiopathic arthritis,” Immunological Investigations, vol. 37, no. 8, pp. 849–857, 2008. View at Publisher · View at Google Scholar · View at Scopus
  29. M. van Rossum, R. van Soesbergen, S. de Kort et al., “Anti-cyclic citrullinated peptide (anti-CCP) antibodies in children with juvenile idiopathic arthritis,” Journal of Rheumatology, vol. 30, no. 4, pp. 825–828, 2003. View at Google Scholar · View at Scopus
  30. P. Dewint, I. E. A. Hoffman, S. Rogge et al., “Effect of age on prevalence of anticitrullinated protein/peptide antibodies in polyarticular juvenile idiopathic arthritis,” Rheumatology, vol. 45, no. 2, pp. 204–208, 2006. View at Publisher · View at Google Scholar · View at Scopus
  31. J. Lipińska, E. Smolewska, H. Brózik, and J. Stańczyk, “Anti-CCP antibodies in children with Juvenile Idiopathic Arthritis (JIA)—diagnostic and clinical significance,” Central-European Journal of Immunology, vol. 33, no. 1, pp. 19–23, 2008. View at Google Scholar · View at Scopus
  32. A. T. Kuna, L. Lamot, M. Miler, M. Harjacek, A.-M. Simundic, and N. Vrkic, “Antibodies to mutated citrullinated vimentin and antibodies to cyclic citrullinated peptides in juvenile idiopathic arthritis,” Clinical Chemistry and Laboratory Medicine, vol. 47, no. 12, pp. 1525–1530, 2009. View at Publisher · View at Google Scholar · View at Scopus
  33. H. Morbach, H. Dannecker, T. Kerkau, and H. J. Girschick, “Prevalence of antibodies against mutated citrullinated vimentin and cyclic citrullinated peptide in children with juvenile idiopathic arthritis,” Clinical and Experimental Rheumatology, vol. 28, no. 5, p. 800, 2010. View at Google Scholar · View at Scopus
  34. B. E. Gilliam, M. R. Reed, A. K. Chauhan, A. B. Dehlendorf, and T. L. Moore, “Evidence of fibrinogen as a target of citrullination in IgM rheumatoid factor-positive polyarticular juvenile idiopathic arthritis,” Pediatric Rheumatology, vol. 9, article 8, 2011. View at Publisher · View at Google Scholar · View at Scopus
  35. T. S. Skare, R. M. Nisihara, R. M. Silva, D. J. Munhoz da Silva, M. B. Gameiro Silva, and S. R. R. Utiyama, “Anti-cyclic citrullinated peptide antibodies in adult patients with juvenile idiopathic arthritis,” Journal of Clinical Rheumatology, vol. 17, no. 8, pp. 421–423, 2011. View at Publisher · View at Google Scholar · View at Scopus
  36. R. Ozawa, Y. Inaba, M. Mori et al., “Definitive differences in laboratory and radiological characteristics between two subtypes of juvenile idiopathic arthritis: Systemic arthritis and polyarthritis,” Modern Rheumatology, vol. 22, no. 4, pp. 558–564, 2012. View at Publisher · View at Google Scholar · View at Scopus
  37. A. E. Tebo, T. Jaskowski, K. W. Davis et al., “Profiling anti-cyclic citrullinated peptide antibodies in patients with juvenile idiopathic arthritis,” Pediatric Rheumatology, vol. 10, article 29, 2012. View at Publisher · View at Google Scholar · View at Scopus
  38. B. E. Gilliam, A. K. Chauhan, and T. L. Moore, “Evaluation of anti-citrullinated type II collagen and anti-citrullinated vimentin antibodies in patients with juvenile idiopathic arthritis,” Pediatric Rheumatology, vol. 11, no. 1, article 31, 2013. View at Publisher · View at Google Scholar · View at Scopus
  39. I. Hromadnikova, K. Stechova, P. Vavrincova et al., “Anti-cyclic citrullinated peptide antibodies in patients with juvenile idiopathic arthritis,” Autoimmunity, vol. 35, no. 6, pp. 397–401, 2002. View at Publisher · View at Google Scholar · View at Scopus
  40. R. H. Syed, B. E. Gilliam, and T. L. Moore, “Rheumatoid factors and anticyclic citrullinated peptide antibodies in pediatric rheumatology,” Current Rheumatology Reports, vol. 10, no. 2, pp. 156–163, 2008. View at Publisher · View at Google Scholar · View at Scopus
  41. P. M. Bossuyt, J. B. Reitsma, D. E. Bruns et al., “Towards complete and accurate reporting of studies of diagnostic accuracy: the STARD initiative,” Annals of Internal Medicine, vol. 138, no. 1, pp. 40–44, 2003. View at Publisher · View at Google Scholar · View at Scopus
  42. L. Irwig, A. N. A. Tosteson, C. Gatsonis et al., “Guidelines for meta-analyses evaluating diagnostic tests,” Annals of Internal Medicine, vol. 120, no. 8, pp. 667–676, 1994. View at Publisher · View at Google Scholar · View at Scopus
  43. R. H. Syed, B. E. Gilliam, and T. L. Moore, “Prevalence and significance of isotypes of anti-cyclic citrullinated peptide antibodies in juvenile idiopathic arthritis,” Annals of the Rheumatic Diseases, vol. 67, no. 7, pp. 1049–1051, 2008. View at Publisher · View at Google Scholar · View at Scopus
  44. A. S. Midgette, T. A. Stukel, and B. Littenberg, “A meta-analytic method for summarizing diagnostic test performances: receiver-operating-characteristic-summary point estimates,” Medical Decision Making, vol. 13, no. 3, pp. 253–257, 1993. View at Publisher · View at Google Scholar · View at Scopus
  45. R. DerSimonian and N. Laird, “Meta-analysis in clinical trials,” Controlled Clinical Trials, vol. 7, no. 3, pp. 177–188, 1986. View at Publisher · View at Google Scholar · View at Scopus
  46. C. Gatsonis and P. Paliwal, “Meta-analysis of diagnostic and screening test accuracy evaluations: methodologic primer,” The American Journal of Roentgenology, vol. 187, no. 2, pp. 271–281, 2006. View at Publisher · View at Google Scholar · View at Scopus
  47. C. M. Rutter and C. A. Gatsonis, “A hierarchical regression approach to meta-analysis of diagnostic test accuracy evaluations,” Statistics in Medicine, vol. 20, no. 19, pp. 2865–2884, 2001. View at Publisher · View at Google Scholar · View at Scopus
  48. A. S. Glas, J. G. Lijmer, M. H. Prins, G. J. Bonsel, and P. M. M. Bossuyt, “The diagnostic odds ratio: a single indicator of test performance,” Journal of Clinical Epidemiology, vol. 56, no. 11, pp. 1129–1135, 2003. View at Publisher · View at Google Scholar · View at Scopus
  49. M. A. Quinn, A. K. S. Gough, M. J. Green et al., “Anti-CCP antibodies measured at disease onset help identify seronegative rheumatoid arthritis and predict radiological and functional outcome,” Rheumatology, vol. 45, no. 4, pp. 478–480, 2006. View at Publisher · View at Google Scholar · View at Scopus
  50. Y. H. Lee, S.-C. Bae, and G. G. Song, “The association between the functional PTPN22 1858 C/T and MIF -173 C/G polymorphisms and juvenile idiopathic arthritis: a meta-analysis,” Inflammation Research, vol. 61, no. 5, pp. 411–415, 2012. View at Publisher · View at Google Scholar · View at Scopus
  51. M. J. Kaalla, K. A. Broadaway, M. Rohani-Pichavant et al., “Meta-analysis confirms association between TNFA-G238A variant and JIA, and between PTPN22-C1858T variant and oligoarticular, RF-polyarticular and RF-positive polyarticular JIA,” Pediatric Rheumatology, vol. 11, no. 1, article 40, 2013. View at Publisher · View at Google Scholar · View at Scopus
  52. M. Haase, R. Bellomo, P. Devarajan, P. Schlattmann, and A. Haase-Fielitz, “Accuracy of neutrophil gelatinase-associated lipocalin (NGAL) in diagnosis and prognosis in acute kidney injury: a systematic review and meta-analysis,” American Journal of Kidney Diseases, vol. 54, no. 6, pp. 1012–1024, 2009. View at Publisher · View at Google Scholar · View at Scopus
  53. H. Visser, S. Le Cessie, K. Vos, F. C. Breedveld, and J. M. W. Hazes, “How to diagnose rheumatoid arthritis early: a prediction model for persistent (erosive) arthritis,” Arthritis and Rheumatism, vol. 46, no. 2, pp. 357–365, 2002. View at Publisher · View at Google Scholar · View at Scopus
  54. L. de Rycke, I. Peene, I. E. A. Hoffman et al., “Rheumatoid factor and anticitrullinated protein antibodies in rheumatoid arthritis: diagnosis value, associations with radiological progression rate, and extra-articular manifestations,” Annals of the Rheumatic Diseases, vol. 63, no. 12, pp. 1587–1593, 2004. View at Publisher · View at Google Scholar · View at Scopus
  55. K. Raza, M. Breese, P. Nightingale et al., “Predictive value of antibodies to cyclic citrullinated peptide in patients with very early inflammatory arthritis,” Journal of Rheumatology, vol. 32, no. 2, pp. 231–238, 2005. View at Google Scholar · View at Scopus
  56. S. Dubucquoi, E. Solau-Gervais, D. Lefranc et al., “Evaluation of anti-citrullinated filaggrin antibodies as hallmarks for the diagnosis of rheumatic diseases,” Annals of the Rheumatic Diseases, vol. 63, no. 4, pp. 415–419, 2004. View at Publisher · View at Google Scholar · View at Scopus
  57. D. M. Lee and P. H. Schur, “Clinical utility of the anti-CCP assay in patients with rheumatic diseases,” Annals of the Rheumatic Diseases, vol. 62, no. 9, pp. 870–874, 2003. View at Publisher · View at Google Scholar · View at Scopus
  58. K. Suzuki, T. Sawada, A. Murakami et al., “High diagnostic performance of ELISA detection of antibodies to citrullinated antigens in rheumatoid arthritis,” Scandinavian Journal of Rheumatology, vol. 32, no. 4, pp. 197–204, 2003. View at Publisher · View at Google Scholar · View at Scopus
  59. P. Kahn, “Juvenile idiopathic arthritis: an update for the clinician,” Bulletin of the NYU Hospital for Joint Diseases, vol. 70, no. 3, pp. 152–166, 2012. View at Google Scholar · View at Scopus
  60. R. Mediwake, D. A. Isenberg, G. A. Schellekens, and W. J. Van Venrooij, “Use of anti-citrullinated peptide and anti-RA33 antibodies in distinguishing erosive arthritis in patients with systemic lupus erythematosus and rheumatoid arthritis,” Annals of the Rheumatic Diseases, vol. 60, no. 1, pp. 67–68, 2001. View at Publisher · View at Google Scholar · View at Scopus
  61. G. A. Schellekens, H. Visser, B. A. de Jong et al., “The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide,” Arthritis & Rheumatism, vol. 43, no. 1, pp. 155–163, 2000. View at Google Scholar
  62. E. A. Goldmuntz and P. H. White, “Juvenile idiopathic arthritis: a review for the pediatrician,” Pediatrics in Review, vol. 27, no. 4, pp. e24–e32, 2006. View at Publisher · View at Google Scholar · View at Scopus
  63. A. Bendersky, V. Marcu-Malina, Y. Berkun et al., “Cellular interactions of synovial fluid gammadelta T cells in juvenile idiopathic arthritis,” Journal of Immunology, vol. 188, no. 9, pp. 4349–4359, 2012. View at Publisher · View at Google Scholar · View at Scopus
  64. W. J. van Venrooij and G. J. M. Pruijn, “Citrullination: a small change for a protein with great consequences for rheumatoid arthritis,” Arthritis Research, vol. 2, no. 4, pp. 249–251, 2000. View at Publisher · View at Google Scholar · View at Scopus
  65. G. A. Schellekens, B. A. W. de Jong, F. H. J. van den Hoogen, L. B. A. van de Putte, and W. J. van Venrooij, “Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies,” The Journal of Clinical Investigation, vol. 101, no. 1, pp. 273–281, 1998. View at Publisher · View at Google Scholar · View at Scopus
  66. N. Bizzaro, G. Mazzanti, E. Tonutti, D. Villalta, and R. Tozzoli, “Diagnostic accuracy of the anti-citrulline antibody assay for rheumatoid arthritis,” Clinical Chemistry, vol. 47, no. 6, pp. 1089–1093, 2001. View at Google Scholar · View at Scopus