Table of Contents Author Guidelines Submit a Manuscript
Journal of Immunology Research
Volume 2016 (2016), Article ID 1058165, 7 pages
http://dx.doi.org/10.1155/2016/1058165
Research Article

CD3+CD8+CD28 T Lymphocytes in Patients with Lupus Nephritis

Department and Clinic of Nephrology and Transplantation Medicine, Faculty of Postgraduate Medical Training, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, Poland

Received 24 February 2016; Revised 28 April 2016; Accepted 1 June 2016

Academic Editor: Oscar Bottasso

Copyright © 2016 Marcelina Żabińska et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The results of studies on the cells in SLE are inconsistent since several analyses describe as either immunosuppressive or cytotoxic. The aim of this study is to inquire whether the quantitative changes of T lymphocytes subpopulation are related to the clinical status of patients with lupus nephritis. Evaluation of Foxp3 expression on cells may shed some light on functional properties of these cells. 54 adult SLE patients and 19 sex and age matched healthy volunteers were enrolled in the study. There were 15 patients in inactive (SLEDAI ≤ 5) and 39 in active (SLEDAI > 5) phase of disease. We determined absolute count of and subpopulations by flow cytometry. We observed a statistically significant increase in absolute count and percentage of in SLE patients compared to HC (). Moreover there was significant positive correlation between increasing absolute count of cells and disease activity measured by SLEDAI (s = 0.281, ). Active LN patients had increased absolute count of cells compared to HC. Positive correlation of number with disease activity, and lack of Foxp3 expression on these cells, suggests that lymphocytes might be responsible for an increased proinflammatory response in the exacerbation of SLE.