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Journal of Immunology Research
Volume 2016, Article ID 1343760, 6 pages
http://dx.doi.org/10.1155/2016/1343760
Research Article

Polymorphism rs3828903 within MICB Is Associated with Susceptibility to Systemic Lupus Erythematosus in a Northern Han Chinese Population

Yue-miao Zhang,1,2,3,4 Xu-jie Zhou,1,2,3,4 Fa-juan Cheng,1,2,3,4 Yuan-yuan Qi,1,2,3,4 Ping Hou,1,2,3,4 Ming-hui Zhao,1,2,3,4 and Hong Zhang1,2,3,4

1Renal Division, Peking University First Hospital, Beijing 100034, China
2Peking University Institute of Nephrology, Beijing 100034, China
3Key Laboratory of Renal Disease, Ministry of Health of China, Beijing 100034, China
4Key Laboratory of Chronic Kidney Disease Prevention and Treatment, Peking University, Ministry of Education, Beijing 100034, China

Received 22 March 2016; Revised 5 June 2016; Accepted 9 June 2016

Academic Editor: Roberta Rizzo

Copyright © 2016 Yue-miao Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objectives. The variant rs3828903 within MICB, a nonclassical MHC class I chain-related gene, was detected to contribute to systemic lupus erythematosus (SLE) in a Caucasian population. This study aimed to investigate the association in a northern Han Chinese population. Methods. We recruited 1077 SLE patients and 793 controls for analysis. rs3828903 was genotyped by TaqMan allele discrimination assay. Using the public databases, its functional annotations and gene differential expression analysis of MICB were evaluated. Results. Significant association between the allele G of rs3828903 and risk susceptibility to SLE was observed after adjusting for sex and age (). In silico analyses predicted a higher affinity to transcription factors for allele G (risk) and cis-expression quantitative trait loci (cis-eQTL) effects of rs3828903 in multiple tissues ( ranging from to ). Furthermore, higher mRNA expressions of MICB were observed in B cells, monocytes, and renal biopsies from SLE patients compared to controls. Conclusion. An association between rs3828903 and susceptibility to SLE has been detected in a Chinese population. This together with the functional annotations of rs3828903 converts MICB into a main candidate in the pathogenesis of SLE.