Polymorphism rs3828903 within MICB Is Associated with Susceptibility to Systemic Lupus Erythematosus in a Northern Han Chinese Population

Figure 1

Systemic lupus erythematosus-associated rs3828903 predicted to be part of the motifs for Zfp740 and Zic_2 in both HaploReg v4.1 and RegulomeDB databases. (a, b) Degeneracy within the 16- and 9-base motifs is illustrated at all positions by the stacked letters at each position. The relative height of each letter is proportional to its overenrichment in the motif. A line is boxed around rs3828903-G; this systemic lupus erythematosus-associated risk allele G is predicted to form the 8th and the second nucleotide in the motifs. (c) Altering the rs3828903 allele from rs3828903-G to rs3828903-A decreases the binding affinity for transcription factors CACD_2, Irf_disc4, Zfp740, and Zic_2 in HaploReg v4.1 database.

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