Selective Subnormal IgG1 in 54 Adult Index Patients with Frequent or Severe Bacterial Respiratory Tract Infections

Table 2

Blood lymphocyte subsets in 54 adults with selective subnormal IgG1.

Lymphocyte subset	Men ()	Women ()	Value of
Median CD19+ cells/µL	160 (76, 432)	228 (64, 576)	0.5281
Subnormal CD19+ cells, % ()	(0)	(0)	~1
Elevated CD19+ cells, % ()	(0)	(0)	~1
Median CD3+/CD4+ cells/µL	1295 (371, 2058)	934 (442, 2984)	0.5976
Subnormal CD3+/CD4+ cells, % ()	(0)	(0)	~1
Elevated CD3+/CD4+ cells, % ()	14.3 ()	10.6 ()	0.5843
Median CD3+/CD8+ cells/µL	641 (237, 1082)	430 (48, 1046)	0.1643
Subnormal CD3+/CD8+ cells, % ()	(0)	2.1 ()	0.8704
Elevated CD3+/CD8+ cells, % ()	14.3 ()	6.4 ()	0.4360
Median CD56+/CD16+ cells/µL	98 (17, 376)	146 (14, 401)	0.4173
Subnormal CD56+/CD16+ cells, % ()	14.3 ()	4.3 ()	0.3463
Elevated CD56+/CD16+ cells, % ()	(0)	(0)	~1

Blood levels of lymphocyte subsets were measured using flow cytometry. Reference ranges (mean ± 2 SD) are as follows: CD19+ 12–645 cells/L; CD3+/CD4+ 359–1,519 cells/L; CD3+/CD8+ 109–897 cells/L; and CD56+/CD16+ 24–406 cells/L. Levels are expressed as median (range). Subnormal levels were defined as those below the corresponding lower reference limits. Elevated levels were defined as those greater than the upper reference limits. Comparisons were made with Mann-Whitney test, Pearson’s test, or Fisher’s exact test, as appropriate.
²These are nominal values of . Bonferroni correction for 12 comparisons yielded a revised for significance of <0.0042.