Selective Subnormal IgG1 in 54 Adult Index Patients with Frequent or Severe Bacterial Respiratory Tract Infections
Table 4
HLA haplotype frequencies in Alabama adults1.
HLA-A
HLA-B
Selective subnormal IgG1 index patients (76 chromosomes)
Controls ( chromosomes)
Value of
01
08
0.1842 ()
0.0925 (1502)
0.0118
37
0.0132 ()
0.0050 (1210)
0.3478
52
0.0132 ()
0 (1502)
0.0488
57
0.0132 ()
0.0066 (1210)
0.4231
02
07
0.0263 ()
0.0413 (1502)
0.3944
15
0.0789 ()
0.0306 (1502)
0.0356
18
0.0132 ()
0.0083 (1210)
0.4897
27
0.0395 ()
0.0083 (1210)
0.0369
35
0.0132 ()
0.0083 (1210)
0.0488
40
0.0395 ()
0.0073 (1502)
0.0266
44
0.0921 ()
0.0633 (1502)
0.3182
45
0.0132 ()
0 (1502)
0.0488
51
0.0132 ()
0.0127 (1502)
0.6297
57
0.0263 ()
0.0047 (1502)
0.0662
03
07
0.0526 ()
0.0546 (1502)
0.6000
14
0.0132 ()
0.0113 (1502)
0.5908
44
0.0132 ()
0.0127 (1502)
0.6297
55
0.0395 ()
0 (1502)
0.0001
11
14
0.0132 ()
0 (1502)
0.0488
18
0.0132 ()
0.0020 (1502)
0.1793
35
0.0526 ()
0.0140 (1502)
0.0291
38
0.0132 ()
0 (1502)
0.0488
51
0.0263 ()
0.0033 (1210)
0.0443
23
18
0.0132 ()
0 (1502)
0.0488
40
0.0132 ()
0 (1502)
0.0488
24
7
0.0132 ()
0.0050 (1210)
0.3478
35
0.0132 ()
0.0060 (1502)
0.0007
44
0.0132 ()
0.0083 (1210)
0.4897
26
35
0.0132 ()
0 (1502)
0.0488
29
44
0.0395 ()
0.0233 (1502)
0.2755
31
40
0.0132 ()
0.0033 (1210)
0.2629
32
8
0.0132 ()
0 (1502)
0.0488
40
0.0132 ()
0 (1502)
0.0488
33
44
0.0132 ()
0 (1502)
0.0488
HLA, human leukocyte antigen. These data represent observations in 38 unrelated white index patients with selective subnormal IgG1 for whom haplotyping observations were available (=76 chromosomes) and other white adults who underwent haplotype analysis for paternity testing. All subjects were residents of Alabama. All haplotypes could be detected with both DNA-based and serologic methods with the exception of haplotypes containing B70 and B72 that were not detected by serologic methods. Results are displayed as % (). Comparisons were made with Fischer’s exact test or Pearson’s chi-square test, as appropriate. 2These are nominal values of . Bonferroni correction for 34 comparisons yielded a revised for significance of <0.0015.
