Dietary Vitamin D Increases Percentages and Function of Regulatory T Cells in the Skin-Draining Lymph Nodes and Suppresses Dermal Inflammation

Figure 3

Dietary vitamin reduced the absolute number of cells in the SDLN. Female offspring born to vitamin D₃- (vitD-) replete (+) or vitamin D₃-deficient (−) BALB/c mothers were maintained on the vitamin D₃-replete or vitamin D₃-deficient diets (resp.). In (a), the number of cells (×10⁷)/mouse or mL of blood isolated from the SDLN, ADLN, MLN, spleen, or blood is shown. The numbers of CD3+CD4+CD25+Foxp3+ ( cells) or CD3+CD4+CD25+Foxp3− ( cells) cells in these tissues were calculated using the percentages depicted in Figure 2. In (b) and (c), the number of CD4+ and cells (×10⁶)/mouse or mL of blood is shown. Data are shown as mean ± SEM for 6 mice/treatment with results combined from two experiments; .

(a)

(b)

(c)