Plasma IL-6/IL-10 Ratio and IL-8, LDH, and HBDH Level Predict the Severity and the Risk of Death in AIDS Patients with Pneumocystis Pneumonia

Figure 2

Receiver operating characteristic (ROC) curve analysis of biomarkers in lighter severity (PaO₂/FiO₂ ≤ 200 mmHg, ) and heavier severity (PaO₂/FiO₂ > 200 mmHg, ) AIDS PCP. (a) LDH (95% CI 0.636–0.956, ), HBDH (95% CI 0.703–0.985, ), and FeP (95% CI 0.657–0.993, ) showing much higher AUC in severity AIDS PCP groups. (b) IL-6 (95% CI 0.704–0.976, ) and IL-8 (95% CI 0.713–0.978, ) showing much higher AUC in severity AIDS PCP groups. (c) IL-8/IL-10 (95% CI 0.671–0.962, ), MCP-1/IL-10 (95% CI 0.559–0.916, ), and IL-6/IL-10 (95% CI 0.781–1.000, ) showing much higher AUC in severity AIDS PCP groups. (d) Much better six biomarkers’ ROC curves shown together (WBC: white blood cell; LDH: lactate dehydrogenase; HBDH: hydroxybutyrate dehydrogenase; IL: interleukin; MCP-1: monocyte chemoattractant protein 1, and FeP: Ferritin protein).

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