CXCL13 Promotes Proliferation of Mesangial Cells by Combination with CXCR5 in SLE

Figure 4

CXCL13 triggered ERK tyrosine phosphorylation. (a) Upon 4 hours, CXCL13 triggered ERK tyrosine phosphorylation of HRMCs as time went on. (b) ERK tyrosine phosphorylation decreased in CXCL13 treatment after the silence of CXCR5 compared to CXCL13 treatment alone. (c) The same result with (a) and (b) was found by immunofluorescence. The top row was detected at 0 hours and the middle at 12 hours after CXCL13 treatment. The bottom presented pERK of cells treating with CXCL13 for 12 hours after transfection.

(a)

(b)

(c)